Search Results
Overview
| Uniprot ID | P27169 |
|---|---|
| Protein Name | Serum paraoxonase/arylesterase 1 |
| Gene Name | PON1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | EKSLLHLKTIRHKLL |
Function
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation
Protein Sequence
10
MAKLIALTLL
20
GMGLALFRNH
30
QSSYQTRLNA
40
LREVQPVELP
50
NCNLVKGIET
60
GSEDLEILPN
70
GLAFISSGLK
80
YPGIKSFNPN
90
SPGKILLMDL
100
NEEDPTVLEL
110
GITGSKFDVS
120
SFNPHGISTF
130
TDEDNAMYLL
140
VVNHPDAKST
150
VELFKFQEEE
160
KSLLHLKTIR
170
HKLLPNLNDI
180
VAVGPEHFYG
190
TNDHYFLDPY
200
LQSWEMYLGL
210
AWSYVVYYSP
220
SEVRVVAEGF
230
DFANGINISP
240
DGKYVYIAEL
250
LAHKIHVYEK
260
HANWTLTPLK
270
SLDFNTLVDN
280
ISVDPETGDL
290
WVGCHPNGMK
300
IFFYDSENPP
310
ASEVLRIQNI
320
LTEEPKVTQV
330
YAENGTVLQG
340
STVASVYKGK
350
LLIGTVFHKA
LYCEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034366 | spherical high-density lipoprotein particle |
| Molecular Function | GO:0102007 | acyl-L-homoserine-lactone lactonohydrolase activity |
| Molecular Function | GO:0004063 | aryldialkylphosphatase activity |
| Molecular Function | GO:0004064 | arylesterase activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0046395 | carboxylic acid catabolic process |
| Biological Process | GO:1901335 | lactone catabolic process |
| Biological Process | GO:0046434 | organophosphate catabolic process |
| Biological Process | GO:0046470 | phosphatidylcholine metabolic process |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0009636 | response to toxic substance |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.