Search Results
Overview
| Uniprot ID | P27321 |
|---|---|
| Protein Name | Calpastatin |
| Gene Name | Cast |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 298 | KSTGESSKAQSAGVT |
Function
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue
Protein Sequence
10
MSRPGPKPAA
20
SSRPRRGAAA
30
SHTQEHVNEK
40
NIGSSSKPAE
50
KKGSDEVTAS
60
SAATGTSPRM
70
STTGAKAVKI
80
ESEKSQSSEP
90
PVIHEKKPKG
100
KPKEGSEPQT
110
LPKHASDTGS
120
KHAHKEKALS
130
RSNEQIVSEK
140
SSESKTKFQD
150
APSADGESVA
160
GGVTVATASD
170
KVVVKKKEKK
180
SLTPTLPMES
190
TLNKLSDKSG
200
VNAALDDLID
210
TLGECEDTNK
220
DDPPYTGPVV
230
LDPMDSTYLE
240
ALGIKEGTIP
250
PEYRKLLEKN
260
EAITGPLPDS
270
PKPMGIDHAI
280
DALSSDFTCS
290
SPTGKQTEKE
300
KSTGESSKAQ
310
SAGVTRSAVP
320
PQEKKRKVEE
330
EVMNDQALQA
340
LSDSLGTRQP
350
DPQSHLRQAK
360
QVKEAKAKEE
370
RQEKCGEDED
380
TVPAEYRLKP
390
AKDKDGKPLL
400
PEPEETSKCL
410
SESELIGELS
420
ADFVQPTYQE
430
KPSMPAAKIK
440
KGVVPDDAVE
450
TLARSLGTRK
460
EDPEDEKSLV
470
DKVKEKAKEE
480
DHEKLGEKEE
490
TIPPDYRLEI
500
VKDKDGKPLL
510
PKEAEEQLPP
520
LSDDFLLDAL
530
SQDFSSPANI
540
LSLGFEDAKL
550
SAAVSETVSQ
560
VPAPSNHTAA
570
PPPGTERRDK
580
ELDDALDELS
590
DSLGQRQPDP
600
DENKPLDDKV
610
KEKIKAEHSE
620
KLGERDDTIP
630
PEYRHLLDND
640
GKDKPEKPLT
650
KNTEKLGQDQ
660
DPIDALSEDL
670
DSCPPTTETS
680
QNTTKEKGKK
690
TSSSKASKNE
700
EKTKDSSKKT
710
EEVPKPKVDE
DAT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0010466 | negative regulation of peptidase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Molecular Function | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0007343 | egg activation |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0045445 | myoblast differentiation |
| Biological Process | GO:0007520 | myoblast fusion |
| Biological Process | GO:0043086 | negative regulation of catalytic activity |
| Biological Process | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process |
| Biological Process | GO:1990709 | presynaptic active zone organization |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0042176 | regulation of protein catabolic process |
| Biological Process | GO:0014732 | skeletal muscle atrophy |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.