Search Results

Overview

Uniprot IDP27338
Protein NameAmine oxidase [flavin-containing] B
Gene NameMAOB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
136 IPSDAPWKAPLAEEW
209 TNGGQERKFVGGSGQ
52 TLRNQKVKYVDLGGS
73 NRILRLAKELGLETY
95 LIHHVKGKSYPFRGP

Function

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). Preferentially degrades benzylamine and phenylethylamine (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924)

Protein Sequence

10 MSNKCDVVVV 20 GGGISGMAAA 30 KLLHDSGLNV 40 VVLEARDRVG 50 GRTYTLRNQK 60 VKYVDLGGSY 70 VGPTQNRILR 80 LAKELGLETY 90 KVNEVERLIH 100 HVKGKSYPFR 110 GPFPPVWNPI 120 TYLDHNNFWR 130 TMDDMGREIP 140 SDAPWKAPLA 150 EEWDNMTMKE 160 LLDKLCWTES 170 AKQLATLFVN 180 LCVTAETHEV 190 SALWFLWYVK 200 QCGGTTRIIS 210 TTNGGQERKF 220 VGGSGQVSER 230 IMDLLGDRVK 240 LERPVIYIDQ 250 TRENVLVETL 260 NHEMYEAKYV 270 ISAIPPTLGM 280 KIHFNPPLPM 290 MRNQMITRVP 300 LGSVIKCIVY 310 YKEPFWRKKD 320 YCGTMIIDGE 330 EAPVAYTLDD 340 TKPEGNYAAI 350 MGFILAHKAR 360 KLARLTKEER 370 LKKLCELYAK 380 VLGSLEALEP 390 VHYEEKNWCE 400 EQYSGGCYTT 410 YFPPGILTQY 420 GRVLRQPVDR 430 IYFAGTETAT 440 HWSGYMEGAV 450 EAGERAAREI 460 LHAMGKIPED 470 EIWQSEPESV 480 DVPAQPITTT 490 FLERHLPSVP 500 GLLRLIGLTT 510 IFSATALGFL 520 AHKRGLLVRV

Gene Ontology

Classification GO ID Description
Biological Process GO:0019607 phenylethylamine catabolic process
Cellular Component GO:0005740 mitochondrial envelope
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0097621 monoamine oxidase activity
Molecular Function GO:0008131 primary methylamine oxidase activity
Biological Process GO:0042420 dopamine catabolic process
Biological Process GO:0050665 hydrogen peroxide biosynthetic process
Biological Process GO:0042428 serotonin metabolic process
Biological Process GO:0021762 substantia nigra development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.