Search Results

Overview

Uniprot IDP27348
Protein Name14-3-3 protein theta
Gene NameYWHAQ
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 TVLELLDKYLIANAT
11 TELIQKAKLAEQAER
122 KVFYLKMKGDYFRYL
139 VACGDDRKQTIDNSQ
158 EAFDISKKEMQPTHP
49 NLLSVAYKNVVGGRR
68 VISSIEQKTDTSDKK
80 DKKLQLIKDYREKVE
85 LIKDYREKVESELRS
9 EKTELIQKAKLAEQA

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1

Protein Sequence

10 MEKTELIQKA 20 KLAEQAERYD 30 DMATCMKAVT 40 EQGAELSNEE 50 RNLLSVAYKN 60 VVGGRRSAWR 70 VISSIEQKTD 80 TSDKKLQLIK 90 DYREKVESEL 100 RSICTTVLEL 110 LDKYLIANAT 120 NPESKVFYLK 130 MKGDYFRYLA 140 EVACGDDRKQ 150 TIDNSQGAYQ 160 EAFDISKKEM 170 QPTHPIRLGL 180 ALNFSVFYYE 190 ILNNPELACT 200 LAKTAFDEAI 210 AELDTLNEDS 220 YKDSTLIMQL 230 LRDNLTLWTS 240 DSAGEECDAA EGAEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0045202 synapse
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0034766 negative regulation of monoatomic ion transmembrane transport
Biological Process GO:0007165 signal transduction
Biological Process GO:0021762 substantia nigra development

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.