Overview
| Uniprot ID | P27448 |
|---|
| Protein Name | MAP/microtubule affinity-regulating kinase 3 |
|---|
| Gene Name | MARK3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 607 |
GSTNLFSKLTSKLTR |
Function
Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695)
Protein Sequence
10
MSTRTPLPTV
20
NERDTENHTS
30
HGDGRQEVTS
40
RTSRSGARCR
50
NSIASCADEQ
60
PHIGNYRLLK
70
TIGKGNFAKV
80
KLARHILTGR
90
EVAIKIIDKT
100
QLNPTSLQKL
110
FREVRIMKIL
120
NHPNIVKLFE
130
VIETEKTLYL
140
IMEYASGGEV
150
FDYLVAHGRM
160
KEKEARSKFR
170
QIVSAVQYCH
180
QKRIVHRDLK
190
AENLLLDADM
200
NIKIADFGFS
210
NEFTVGGKLD
220
TFCGSPPYAA
230
PELFQGKKYD
240
GPEVDVWSLG
250
VILYTLVSGS
260
LPFDGQNLKE
270
LRERVLRGKY
280
RIPFYMSTDC
290
ENLLKRFLVL
300
NPIKRGTLEQ
310
IMKDRWINAG
320
HEEDELKPFV
330
EPELDISDQK
340
RIDIMVGMGY
350
SQEEIQESLS
360
KMKYDEITAT
370
YLLLGRKSSE
380
LDASDSSSSS
390
NLSLAKVRPS
400
SDLNNSTGQS
410
PHHKVQRSVS
420
SSQKQRRYSD
430
HAGPAIPSVV
440
AYPKRSQTST
450
ADSDLKEDGI
460
SSRKSSGSAV
470
GGKGIAPASP
480
MLGNASNPNK
490
ADIPERKKSS
500
TVPSSNTASG
510
GMTRRNTYVC
520
SERTTADRHS
530
VIQNGKENST
540
IPDQRTPVAS
550
THSISSAATP
560
DRIRFPRGTA
570
SRSTFHGQPR
580
ERRTATYNGP
590
PASPSLSHEA
600
TPLSQTRSRG
610
STNLFSKLTS
620
KLTRRNMSFR
630
FIKRLPTEYE
640
RNGRYEGSSR
650
NVSAEQKDEN
660
KEAKPRSLRF
670
TWSMKTTSSM
680
DPGDMMREIR
690
KVLDANNCDY
700
EQRERFLLFC
710
VHGDGHAENL
720
VQWEMEVCKL
730
PRLSLNGVRF
740
KRISGTSIAF
750
KNIASKIANE
LKL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0019903 |
protein phosphatase binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Molecular Function |
GO:0048156 |
tau protein binding |
| Molecular Function |
GO:0050321 |
tau-protein kinase activity |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0000226 |
microtubule cytoskeleton organization |
| Biological Process |
GO:0035331 |
negative regulation of hippo signaling |
| Biological Process |
GO:1900181 |
negative regulation of protein localization to nucleus |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.