Overview
| Uniprot ID | P27487 |
|---|
| Protein Name | Dipeptidyl peptidase 4 |
|---|
| Gene Name | DPP4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 139 |
YDIYDLNKRQLITEE |
| 258 |
TVRVPYPKAGAVNPT |
| 41 |
DATADSRKTYTLTDY |
| 56 |
LKNTYRLKLYSLRWI |
Function
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:10593948, PubMed:16651416). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:10570924, PubMed:16254193). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948)
Protein Sequence
10
MKTPWKVLLG
20
LLGAAALVTI
30
ITVPVVLLNK
40
GTDDATADSR
50
KTYTLTDYLK
60
NTYRLKLYSL
70
RWISDHEYLY
80
KQENNILVFN
90
AEYGNSSVFL
100
ENSTFDEFGH
110
SINDYSISPD
120
GQFILLEYNY
130
VKQWRHSYTA
140
SYDIYDLNKR
150
QLITEERIPN
160
NTQWVTWSPV
170
GHKLAYVWNN
180
DIYVKIEPNL
190
PSYRITWTGK
200
EDIIYNGITD
210
WVYEEEVFSA
220
YSALWWSPNG
230
TFLAYAQFND
240
TEVPLIEYSF
250
YSDESLQYPK
260
TVRVPYPKAG
270
AVNPTVKFFV
280
VNTDSLSSVT
290
NATSIQITAP
300
ASMLIGDHYL
310
CDVTWATQER
320
ISLQWLRRIQ
330
NYSVMDICDY
340
DESSGRWNCL
350
VARQHIEMST
360
TGWVGRFRPS
370
EPHFTLDGNS
380
FYKIISNEEG
390
YRHICYFQID
400
KKDCTFITKG
410
TWEVIGIEAL
420
TSDYLYYISN
430
EYKGMPGGRN
440
LYKIQLSDYT
450
KVTCLSCELN
460
PERCQYYSVS
470
FSKEAKYYQL
480
RCSGPGLPLY
490
TLHSSVNDKG
500
LRVLEDNSAL
510
DKMLQNVQMP
520
SKKLDFIILN
530
ETKFWYQMIL
540
PPHFDKSKKY
550
PLLLDVYAGP
560
CSQKADTVFR
570
LNWATYLAST
580
ENIIVASFDG
590
RGSGYQGDKI
600
MHAINRRLGT
610
FEVEDQIEAA
620
RQFSKMGFVD
630
NKRIAIWGWS
640
YGGYVTSMVL
650
GSGSGVFKCG
660
IAVAPVSRWE
670
YYDSVYTERY
680
MGLPTPEDNL
690
DHYRNSTVMS
700
RAENFKQVEY
710
LLIHGTADDN
720
VHFQQSAQIS
730
KALVDVGVDF
740
QAMWYTDEDH
750
GIASSTAHQH
760
IYTHMSHFIK
QCFSLP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0030139 |
endocytic vesicle |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0046581 |
intercellular canaliculus |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0031258 |
lamellipodium membrane |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0004177 |
aminopeptidase activity |
| Molecular Function |
GO:0045499 |
chemorepellent activity |
| Molecular Function |
GO:0008239 |
dipeptidyl-peptidase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0002020 |
protease binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0004252 |
serine-type endopeptidase activity |
| Molecular Function |
GO:0008236 |
serine-type peptidase activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0001618 |
virus receptor activity |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0043542 |
endothelial cell migration |
| Biological Process |
GO:0120116 |
glucagon processing |
| Biological Process |
GO:0061025 |
membrane fusion |
| Biological Process |
GO:0010716 |
negative regulation of extracellular matrix disassembly |
| Biological Process |
GO:0090024 |
negative regulation of neutrophil chemotaxis |
| Biological Process |
GO:0016486 |
peptide hormone processing |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0019065 |
receptor-mediated endocytosis of virus by host cell |
| Biological Process |
GO:0046813 |
receptor-mediated virion attachment to host cell |
| Biological Process |
GO:0033632 |
regulation of cell-cell adhesion mediated by integrin |
| Biological Process |
GO:0001666 |
response to hypoxia |
| Biological Process |
GO:0046718 |
symbiont entry into host cell |
| Biological Process |
GO:0042110 |
T cell activation |
| Biological Process |
GO:0031295 |
T cell costimulation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.