Search Results

Overview

Uniprot ID	P27540
Protein Name	Aryl hydrocarbon receptor nuclear translocator
Gene Name	ARNT
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
104	IERRRRNKMTAYITE
128	ALARKPDKLTILRMA
240	TGRILDLKTGTVKKE

Function

Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target gene promoters (PubMed:28396409, PubMed:34521881). Also heterodimerizes with hypoxia-inducible factor alpha subunits (HIF1A, EPAS1, NPAS1 or NPAS3) to form hypoxia-inducible transcription factors that bind hypoxia response elements (HREs) and activate genes involved in cellular and systemic responses to hypoxia, including angiogenesis, erythropoiesis, and metabolic adaptation (PubMed:16181639, PubMed:20699359). Plays a central role in environmental sensing and developmental and physiological regulation of gene expression (PubMed:34521881)

Protein Sequence

10 MAATTANPEM 20 TSDVPSLGPA 30 IASGNSGPGI 40 QGGGAIVQRA 50 IKRRPGLDFD 60 DDGEGNSKFL 70 RCDDDQMSND 80 KERFARSDDE 90 QSSADKERLA 100 RENHSEIERR 110 RRNKMTAYIT 120 ELSDMVPTCS 130 ALARKPDKLT 140 ILRMAVSHMK 150 SLRGTGNTST 160 DGSYKPSFLT 170 DQELKHLILE 180 AADGFLFIVS 190 CETGRVVYVS 200 DSVTPVLNQP 210 QSEWFGSTLY 220 DQVHPDDVDK 230 LREQLSTSEN 240 ALTGRILDLK 250 TGTVKKEGQQ 260 SSMRMCMGSR 270 RSFICRMRCG 280 SSSVDPVSVN 290 RLSFVRNRCR 300 NGLGSVKDGE 310 PHFVVVHCTG 320 YIKAWPPAGV 330 SLPDDDPEAG 340 QGSKFCLVAI 350 GRLQVTSSPN 360 CTDMSNVCQP 370 TEFISRHNIE 380 GIFTFVDHRC 390 VATVGYQPQE 400 LLGKNIVEFC 410 HPEDQQLLRD 420 SFQQVVKLKG 430 QVLSVMFRFR 440 SKNQEWLWMR 450 TSSFTFQNPY 460 SDEIEYIICT 470 NTNVKNSSQE 480 PRPTLSNTIQ 490 RPQLGPTANL 500 PLEMGSGQLA 510 PRQQQQQTEL 520 DMVPGRDGLA 530 SYNHSQVVQP 540 VTTTGPEHSK 550 PLEKSDGLFA 560 QDRDPRFSEI 570 YHNINADQSK 580 GISSSTVPAT 590 QQLFSQGNTF 600 PPTPRPAENF 610 RNSGLAPPVT 620 IVQPSASAGQ 630 MLAQISRHSN 640 PTQGATPTWT 650 PTTRSGFSAQ 660 QVATQATAKT 670 RTSQFGVGSF 680 QTPSSFSSMS 690 LPGAPTASPG 700 AAAYPSLTNR 710 GSNFAPETGQ 720 TAGQFQTRTA 730 EGVGVWPQWQ 740 GQQPHHRSSS 750 SEQHVQQPPA 760 QQPGQPEVFQ 770 EMLSMLGDQS 780 NSYNNEEFPD LTMFPPFSE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0034751	aryl hydrocarbon receptor complex
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0034753	nuclear aryl hydrocarbon receptor complex
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex
Molecular Function	GO:0017162	aryl hydrocarbon receptor binding
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0004879	nuclear receptor activity
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0050728	negative regulation of inflammatory response
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation
Biological Process	GO:0045821	positive regulation of glycolytic process
Biological Process	GO:0046886	positive regulation of hormone biosynthetic process
Biological Process	GO:0033235	positive regulation of protein sumoylation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0006805	xenobiotic metabolic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.