Search Results
Overview
| Uniprot ID | P27594 |
|---|---|
| Protein Name | Interferon-induced GTP-binding protein Mx1 |
| Gene Name | MX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | TRCPLVLKLKKLVNE |
| 113 | PLVLKLKKLVNEEDE |
| 260 | VDKGTEDKIVDVARN |
| 421 | RWSAVVEKNFKNGYD |
| 460 | KTFETIIKKQVSVLE |
| 516 | DIKLEQEKEAETSIR |
Function
Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles
Protein Sequence
10
MVYSSCESKE
20
PDSVSASNHL
30
LLNGNDELVE
40
KSHKTGPENN
50
LYSQYEEKVR
60
PCIDLIDSLR
70
ALGVEQDLAL
80
PAIAVIGDQS
90
SGKSSVLEAL
100
SGVALPRGSG
110
IVTRCPLVLK
120
LKKLVNEEDE
130
WKGKVSYRDS
140
EIELSDASQV
150
EKEVSAAQIA
160
IAGEGVGISH
170
ELISLEVSSP
180
HVPDLTLIDL
190
PGITRVAVGN
200
QPYDIEYQIK
210
SLIKKYICKQ
220
ETINLVVVPC
230
NVDIATTEAL
240
RMAQEVDPEG
250
DRTIGILTKP
260
DLVDKGTEDK
270
IVDVARNLVF
280
HLKKGYMIVK
290
CRGQQDIQEQ
300
LSLAKALQKE
310
QAFFENHAHF
320
RDLLEEGRAT
330
IPCLAERLTS
340
ELIMHICKTL
350
PLLENQIKES
360
HQKITEELQK
370
YGSDIPEDES
380
GKMFFLIDKI
390
DAFNSDITAL
400
IQGEELVVEY
410
ECRLFTKMRN
420
EFCRWSAVVE
430
KNFKNGYDAI
440
CKQIQLFENQ
450
YRGRELPGFV
460
NYKTFETIIK
470
KQVSVLEEPA
480
VDMLHTVTDL
490
VRLAFTDVSE
500
TNFNEFFNLH
510
RTAKSKIEDI
520
KLEQEKEAET
530
SIRLHFQMEQ
540
IVYCQDQVYR
550
GALQKVREKE
560
AEEEKNRKSN
570
QYFLSSPAPS
580
SDPSIAEIFQ
590
HLIAYHQEVG
600
KRISSHIPLI
610
IQFFILRTFG
620
QQLQKSMLQL
630
LQNKDQYDWL
640
LRERSDTSDK
650
RKFLKERLMR
660
LTQARRRLAK
FPG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Biological Process | GO:0071357 | cellular response to type I interferon |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:1901253 | negative regulation of intracellular transport of viral material |
| Biological Process | GO:0045071 | negative regulation of viral genome replication |
| Biological Process | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.