Search Results

Overview

Uniprot IDP27816
Protein NameMicrotubule-associated protein 4
Gene NameMAP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1007 SYSHIQSKCGSKDNI
1011 IQSKCGSKDNIKHVP
1015 CGSKDNIKHVPGGGN
1028 GNVQIQNKKVDISKV
1029 NVQIQNKKVDISKVS
1034 NKKVDISKVSSKCGS
1060 DVKIESQKLNFKEKA
1070 FKEKAQAKVGSLDNV
254 TTDMAPSKETEMALA
269 KDMALATKTEVALAK
276 KTEVALAKDMESPTK
318 EKEVALVKDVRWPTE
352 AKDVTLLKETERASP
361 TERASPIKMDLAPSK
368 KMDLAPSKDMGPPKE
387 TERASPIKMDLAPSK
394 KMDLAPSKDMGPPKE
403 MGPPKENKIVPAKDL
464 NVILTKDKALPLEAE
498 DVAPSTVKEVGLLKD
560 KTEAPLAKDGVLTLA
634 TVTGTGKKCSLPAEE
711 LATTQPAKTSTSKAK
718 KTSTSKAKTQPTSLP
726 TQPTSLPKQPAPTTI
738 TTIGGLNKKPMSLAS
739 TIGGLNKKPMSLASG
769 RPSILPSKDVKPKPI
780 PKPIADAKAPEKRAS
802 PASRSGSKSTQTVAK
809 KSTQTVAKTTTAAAV
852 EVKKMTAKSVPADLS
871 TSTSSMKKTTTLSGT
890 GVVPSRVKATPMPSR
933 NTSAPDLKNVRSKVG
938 DLKNVRSKVGSTENI
976 PESNAVTKTAGPIAS
986 GPIASAQKQPAGKVQ
991 AQKQPAGKVQIVSKK
997 GKVQIVSKKVSYSHI
998 KVQIVSKKVSYSHIQ

Function

Non-neuronal microtubule-associated protein. Promotes microtubule assembly

Protein Sequence

10 MADLSLADAL 20 TEPSPDIEGE 30 IKRDFIATLE 40 AEAFDDVVGE 50 TVGKTDYIPL 60 LDVDEKTGNS 70 ESKKKPCSET 80 SQIEDTPSSK 90 PTLLANGGHG 100 VEGSDTTGSP 110 TEFLEEKMAY 120 QEYPNSQNWP 130 EDTNFCFQPE 140 QVVDPIQTDP 150 FKMYHDDDLA 160 DLVFPSSATA 170 DTSIFAGQND 180 PLKDSYGMSP 190 CNTAVVPQGW 200 SVEALNSPHS 210 ESFVSPEAVA 220 EPPQPTAVPL 230 ELAKEIEMAS 240 EERPPAQALE 250 IMMGLKTTDM 260 APSKETEMAL 270 AKDMALATKT 280 EVALAKDMES 290 PTKLDVTLAK 300 DMQPSMESDM 310 ALVKDMELPT 320 EKEVALVKDV 330 RWPTETDVSS 340 AKNVVLPTET 350 EVAPAKDVTL 360 LKETERASPI 370 KMDLAPSKDM 380 GPPKENKKET 390 ERASPIKMDL 400 APSKDMGPPK 410 ENKIVPAKDL 420 VLLSEIEVAQ 430 ANDIISSTEI 440 SSAEKVALSS 450 ETEVALARDM 460 TLPPETNVIL 470 TKDKALPLEA 480 EVAPVKDMAQ 490 LPETEIAPAK 500 DVAPSTVKEV 510 GLLKDMSPLS 520 ETEMALGKDV 530 TPPPETEVVL 540 IKNVCLPPEM 550 EVALTEDQVP 560 ALKTEAPLAK 570 DGVLTLANNV 580 TPAKDVPPLS 590 ETEATPVPIK 600 DMEIAQTQKG 610 ISEDSHLESL 620 QDVGQSAAPT 630 FMISPETVTG 640 TGKKCSLPAE 650 EDSVLEKLGE 660 RKPCNSQPSE 670 LSSETSGIAR 680 PEEGRPVVSG 690 TGNDITTPPN 700 KELPPSPEKK 710 TKPLATTQPA 720 KTSTSKAKTQ 730 PTSLPKQPAP 740 TTIGGLNKKP 750 MSLASGLVPA 760 APPKRPAVAS 770 ARPSILPSKD 780 VKPKPIADAK 790 APEKRASPSK 800 PASAPASRSG 810 SKSTQTVAKT 820 TTAAAVASTG 830 PSSRSPSTLL 840 PKKPTAIKTE 850 GKPAEVKKMT 860 AKSVPADLSR 870 PKSTSTSSMK 880 KTTTLSGTAP 890 AAGVVPSRVK 900 ATPMPSRPST 910 TPFIDKKPTS 920 AKPSSTTPRL 930 SRLATNTSAP 940 DLKNVRSKVG 950 STENIKHQPG 960 GGRAKVEKKT 970 EAAATTRKPE 980 SNAVTKTAGP 990 IASAQKQPAG 1000 KVQIVSKKVS 1010 YSHIQSKCGS 1020 KDNIKHVPGG 1030 GNVQIQNKKV 1040 DISKVSSKCG 1050 SKANIKHKPG 1060 GGDVKIESQK 1070 LNFKEKAQAK 1080 VGSLDNVGHL 1090 PAGGAVKTEG 1100 GGSEAPLCPG 1110 PPAGEEPAIS 1120 EAAPEAGAPT 1130 SASGLNGHPT 1140 LSGGGDQREA 1150 QTLDSQIQET SI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Biological Process GO:0051294 establishment of spindle orientation
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0046785 microtubule polymerization
Biological Process GO:0051012 microtubule sliding
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:1902856 negative regulation of non-motile cilium assembly
Biological Process GO:0031175 neuron projection development
Cellular Component GO:0005930 axoneme
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005929 cilium
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0043005 neuron projection
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0140778 microtubule stabilizing activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0051301 cell division
Biological Process GO:0061523 cilium disassembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.