Search Results
Overview
| Uniprot ID | P27881 |
|---|---|
| Protein Name | Hexokinase-2 |
| Gene Name | Hk2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 295 | PGKQLFEKMISGMYM |
Function
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:5871820). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:5871820). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (By similarity)
Protein Sequence
10
MIASHMIACL
20
FTELNQNQVQ
30
KVDQFLYHMR
40
LSDETLLEIS
50
RRFRKEMEKG
60
LGATTHPTAA
70
VKMLPTFVRS
80
TPDGTEHGEF
90
LALDLGGTNF
100
RVLRVRVTDN
110
GLQRVEMENQ
120
IYAIPEDIMR
130
GSGTQLFDHI
140
AECLANFMDK
150
LQIKEKKLPL
160
GFTFSFPCHQ
170
TKLDESFLVS
180
WTKGFKSSGV
190
EGRDVVDLIR
200
KAIQRRGDFD
210
IDIVAVVNDT
220
VGTMMTCGYD
230
DQNCEIGLIV
240
GTGSNACYME
250
EMRHIDMVEG
260
DEGRMCINME
270
WGAFGDDGTL
280
NDIRTEFDRE
290
IDMGSLNPGK
300
QLFEKMISGM
310
YMGELVRLIL
320
VKMAKAELLF
330
QGKLSPELLT
340
TGSFETKDVS
350
DIEEDKDGIE
360
KAYQILMRLG
370
LNPLQEDCVA
380
THRICQIVST
390
RSASLCAATL
400
AAVLWRIKEN
410
KGEERLRSTI
420
GVDGSVYKKH
430
PHFAKRLHKA
440
VRRLVPDCDV
450
RFLRSEDGSG
460
KGAAMVTAVA
470
YRLADQHRAR
480
QKTLESLKLS
490
HEQLLEVKRR
500
MKVEMEQGLS
510
KETHAVAPVK
520
MLPTYVCATP
530
DGTEKGDFLA
540
LDLGGTNFRV
550
LLVRVRNGKR
560
RGVEMHNKIY
570
SIPQEVMHGT
580
GEELFDHIVQ
590
CIADFLEYMG
600
MKGVSLPLGF
610
TFSFPCQQNS
620
LDQSILLKWT
630
KGFKASGCEG
640
EDVVTLLKEA
650
IHRREEFDLD
660
VVAVVNDTVG
670
TMMTCGYEDP
680
HCEVGLIVGT
690
GSNACYMEEM
700
RNVELVDGEE
710
GRMCVNMEWG
720
AFGDNGCLDD
730
LRTVFDVAVD
740
ELSLNPGKQR
750
FEKMISGMYL
760
GEIVRNILID
770
FTKRGLLFRG
780
RISERLKTRG
790
IFETKFLSQI
800
ESDCLALLQV
810
RAILRHLGLE
820
STCDDSIIVK
830
EVCTVVARRA
840
AQLCGAGMAA
850
VVDKIRENRG
860
LDNLKVTVGV
870
DGTLYKLHPH
880
FAKVMHETVR
890
DLAPKCDVSF
900
LESEDGSGKG
910
AALITAVACR
IREAGQR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005536 | D-glucose binding |
| Molecular Function | GO:0008865 | fructokinase activity |
| Molecular Function | GO:0004340 | glucokinase activity |
| Molecular Function | GO:0004396 | hexokinase activity |
| Biological Process | GO:0008637 | apoptotic mitochondrial changes |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0046835 | carbohydrate phosphorylation |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0072655 | establishment of protein localization to mitochondrion |
| Biological Process | GO:0006002 | fructose 6-phosphate metabolic process |
| Biological Process | GO:0051156 | glucose 6-phosphate metabolic process |
| Biological Process | GO:0006007 | glucose catabolic process |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0001678 | intracellular glucose homeostasis |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0072656 | maintenance of protein location in mitochondrion |
| Biological Process | GO:0035795 | negative regulation of mitochondrial membrane permeability |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:1905091 | positive regulation of type 2 mitophagy |
| Biological Process | GO:0046324 | regulation of D-glucose import across plasma membrane |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0002931 | response to ischemia |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.