Overview
| Uniprot ID | P27952 |
|---|
| Protein Name | Small ribosomal subunit protein uS5 |
|---|
| Gene Name | Rps2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 211 |
IVSAPVPKKLLMMAG |
Function
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)
Protein Sequence
10
MADDAGAAGG
20
PGGPGGPGLG
30
GRGGFRGGFG
40
SGLRGRGRGR
50
GRGRGRGRGA
60
RGGKAEDKEW
70
IPVTKLGRLV
80
KDMKIKSLEE
90
IYLFSLPIKE
100
SEIIDFFLGA
110
SLKDEVLKIM
120
PVQKQTRAGQ
130
RTRFKAFVAI
140
GDYNGHVGLG
150
VKCSKEVATA
160
IRGAIILAKL
170
SIVPVRRGYW
180
GNKIGKPHTV
190
PCKVTGRCGS
200
VLVRLIPAPR
210
GTGIVSAPVP
220
KKLLMMAGID
230
DCYTSARGCT
240
ATLGNFAKAT
250
FDAISKTYSY
260
LTPDLWKETV
270
FTKSPYQEFT
280
DHLVKTHTRV
290
SVQRTQAPAV
ATT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0022626 |
cytosolic ribosome |
| Cellular Component |
GO:0022627 |
cytosolic small ribosomal subunit |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0017134 |
fibroblast growth factor binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Biological Process |
GO:0071353 |
cellular response to interleukin-4 |
| Biological Process |
GO:0001731 |
formation of translation preinitiation complex |
| Biological Process |
GO:0051443 |
positive regulation of ubiquitin-protein transferase activity |
| Biological Process |
GO:0045471 |
response to ethanol |
| Biological Process |
GO:0000028 |
ribosomal small subunit assembly |
| Biological Process |
GO:0006412 |
translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.