Search Results

Overview

Uniprot IDP28037
Protein NameCytosolic 10-formyltetrahydrofolate dehydrogenase
Gene NameAldh1l1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
669 CALSNVKKVSLELGG

Function

Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:10585460, PubMed:17302434, PubMed:17884809, PubMed:1848231, PubMed:7822273). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (PubMed:1848231)

Protein Sequence

10 MKIAVIGQSL 20 FGQEVYCQLR 30 KEGHEVVGVF 40 TIPDKDGKAD 50 PLGLEAEKDG 60 VPVFKFPRWR 70 ARGQALPEVV 80 AKYQALGAEL 90 NVLPFCSQFI 100 PMEVINAPRH 110 GSIIYHPSLL 120 PRHRGASAIN 130 WTLIHGDKKG 140 GFTIFWADDG 150 LDTGDLLLQK 160 ECEVLPDDTV 170 STLYNRFLFP 180 EGIKGMVQAV 190 RLIAEGTAPR 200 CPQSEEGATY 210 EGIQKKETAK 220 INWDQPAEAI 230 HNWIRGNDKV 240 PGAWTEACGQ 250 KLTFFNSTLN 260 TSGLSTQGEA 270 LPIPGAHRPG 280 VVTKAGLILF 290 GNDDRMLLVK 300 NIQLEDGKMM 310 PASQFFKGSA 320 SSDLELTEAE 330 LATAEAVRSS 340 WMRILPNVPE 350 VEDSTDFFKS 360 GAASVDVVRL 370 VEEVKELCDG 380 LELENEDVYM 390 ATTFRGFIQL 400 LVRKLRGEDD 410 ESECVINYVE 420 KAVNKLTLQM 430 PYQLFIGGEF 440 VDAEGSKTYN 450 TINPTDGSVI 460 CQVSLAQVSD 470 VDKAVAAAKE 480 AFENGLWGKI 490 NARDRGRLLY 500 RLADVMEQHQ 510 EELATIEALD 520 AGAVYTLALK 530 THVGMSIQTF 540 RYFAGWCDKI 550 QGATIPINQA 560 RPNRNLTLTK 570 KEPVGVCGIV 580 IPWNYPLMML 590 SWKTAACLAA 600 GNTVVIKPAQ 610 VTPLTALKFA 620 ELTLKAGIPK 630 GVVNILPGSG 640 SLVGQRLSDH 650 PDVRKIGFTG 660 STEVGKHIMK 670 SCALSNVKKV 680 SLELGGKSPL 690 IIFADCDLNK 700 AVQMGMSSVF 710 FNKGENCIAA 720 GRLFVEESIH 730 NQFVQKVVEE 740 VEKMKIGNPL 750 ERDTNHGPQN 760 HEAHLRKLVE 770 YCQRGVKEGA 780 TLVCGGNQVP 790 RPGFFFQPTV 800 FTDVEDHMYI 810 AKEESFGPIM 820 IISRFADGDV 830 DAVLSRANAT 840 EFGLASGVFT 850 RDINKALYVS 860 DKLQAGTVFI 870 NTYNKTDVAA 880 PFGGFKQSGF 890 GKDLGEAALN 900 EYLRIKTVTF EY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0033721 aldehyde dehydrogenase (NADP+) activity
Molecular Function GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
Molecular Function GO:0016155 formyltetrahydrofolate dehydrogenase activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0009258 10-formyltetrahydrofolate catabolic process
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0006740 NADPH regeneration
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
Biological Process GO:0035999 tetrahydrofolate interconversion

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.