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Overview

Uniprot IDP28070
Protein NameProteasome subunit beta type-4
Gene NamePSMB4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
201 LLREVLEKQPVLSQT

Function

Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1

Protein Sequence

10 MEAFLGSRSG 20 LWAGGPAPGQ 30 FYRIPSTPDS 40 FMDPASALYR 50 GPITRTQNPM 60 VTGTSVLGVK 70 FEGGVVIAAD 80 MLGSYGSLAR 90 FRNISRIMRV 100 NNSTMLGASG 110 DYADFQYLKQ 120 VLGQMVIDEE 130 LLGDGHSYSP 140 RAIHSWLTRA 150 MYSRRSKMNP 160 LWNTMVIGGY 170 ADGESFLGYV 180 DMLGVAYEAP 190 SLATGYGAYL 200 AQPLLREVLE 210 KQPVLSQTEA 220 RDLVERCMRV 230 LYYRDARSYN 240 RFQIATVTEK 250 GVEIEGPLST 260 ETNWDIAHMI SGFE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005839 proteasome core complex
Cellular Component GO:0019774 proteasome core complex, beta-subunit complex
Cellular Component GO:0034515 proteasome storage granule
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0001530 lipopolysaccharide binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0043374 CD8-positive, alpha-beta T cell differentiation
Biological Process GO:0160165 CD8-positive, alpha-beta T cell homeostasis
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006281 DNA repair
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0002376 immune system process
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0002862 negative regulation of inflammatory response to antigenic stimulus
Biological Process GO:0045590 negative regulation of regulatory T cell differentiation
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0032729 positive regulation of type II interferon production
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0010499 proteasomal ubiquitin-independent protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0034341 response to type II interferon
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0045063 T-helper 1 cell differentiation
Biological Process GO:0072539 T-helper 17 cell differentiation
Biological Process GO:0045061 thymic T cell selection

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.