Overview
| Uniprot ID | P28072 |
|---|
| Protein Name | Proteasome subunit beta type-6 |
|---|
| Gene Name | PSMB6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 67 |
IANRVTDKLTPIHDR |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues
Protein Sequence
10
MAATLLAARG
20
AGPAPAWGPE
30
AFTPDWESRE
40
VSTGTTIMAV
50
QFDGGVVLGA
60
DSRTTTGSYI
70
ANRVTDKLTP
80
IHDRIFCCRS
90
GSAADTQAVA
100
DAVTYQLGFH
110
SIELNEPPLV
120
HTAASLFKEM
130
CYRYREDLMA
140
GIIIAGWDPQ
150
EGGQVYSVPM
160
GGMMVRQSFA
170
IGGSGSSYIY
180
GYVDATYREG
190
MTKEECLQFT
200
ANALALAMER
210
DGSSGGVIRL
220
AAIAESGVER
230
QVLLGDQIPK
FAVATLPPA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0005839 |
proteasome core complex |
| Cellular Component |
GO:0019774 |
proteasome core complex, beta-subunit complex |
| Cellular Component |
GO:0034515 |
proteasome storage granule |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0004175 |
endopeptidase activity |
| Molecular Function |
GO:0004298 |
threonine-type endopeptidase activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0071357 |
cellular response to type I interferon |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0030317 |
flagellated sperm motility |
| Biological Process |
GO:0051321 |
meiotic cell cycle |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0010499 |
proteasomal ubiquitin-independent protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:2000045 |
regulation of G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.