Search Results
Overview
| Uniprot ID | P28161 |
|---|---|
| Protein Name | Glutathione S-transferase Mu 2 |
| Gene Name | GSTM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 211 | LPRPVFTKMAVWGNK |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276)
Protein Sequence
10
MPMTLGYWNI
20
RGLAHSIRLL
30
LEYTDSSYEE
40
KKYTMGDAPD
50
YDRSQWLNEK
60
FKLGLDFPNL
70
PYLIDGTHKI
80
TQSNAILRYI
90
ARKHNLCGES
100
EKEQIREDIL
110
ENQFMDSRMQ
120
LAKLCYDPDF
130
EKLKPEYLQA
140
LPEMLKLYSQ
150
FLGKQPWFLG
160
DKITFVDFIA
170
YDVLERNQVF
180
EPSCLDAFPN
190
LKDFISRFEG
200
LEKISAYMKS
210
SRFLPRPVFT
KMAVWGNK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0070458 | cellular detoxification of nitrogen compound |
| Biological Process | GO:0071313 | cellular response to caffeine |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0018916 | nitrobenzene metabolic process |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.