Search Results
Overview
| Uniprot ID | P28332 |
|---|---|
| Protein Name | Alcohol dehydrogenase 6 |
| Gene Name | ADH6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | CIQFKQSKTQLMSDG |
| 136 | SRFTCKGKSIYHFGN |
| 227 | IIGVDVNKEKFKKAQ |
| 232 | VNKEKFKKAQELGAT |
| 248 | CLNPQDLKKPIQEVL |
| 316 | FFSGRSLKGSVFGGW |
| 33 | EVEVAPPKAKEVRIK |
| 364 | NEAVELMKTGKW*** |
| 40 | KAKEVRIKVVATGLC |
| 52 | GLCGTEMKVLGSKHL |
| 57 | EMKVLGSKHLDLLYP |
Function
Alcohol dehydrogenase (PubMed:1755855). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (PubMed:1755855). Oxidizes secondary alcohols to the corresponding ketones (By similarity)
Protein Sequence
10
MSTTGQVIRC
20
KAAILWKPGA
30
PFSIEEVEVA
40
PPKAKEVRIK
50
VVATGLCGTE
60
MKVLGSKHLD
70
LLYPTILGHE
80
GAGIVESIGE
90
GVSTVKPGDK
100
VITLFLPQCG
110
ECTSCLNSEG
120
NFCIQFKQSK
130
TQLMSDGTSR
140
FTCKGKSIYH
150
FGNTSTFCEY
160
TVIKEISVAK
170
IDAVAPLEKV
180
CLISCGFSTG
190
FGAAINTAKV
200
TPGSTCAVFG
210
LGGVGLSVVM
220
GCKAAGAARI
230
IGVDVNKEKF
240
KKAQELGATE
250
CLNPQDLKKP
260
IQEVLFDMTD
270
AGIDFCFEAI
280
GNLDVLAAAL
290
ASCNESYGVC
300
VVVGVLPASV
310
QLKISGQLFF
320
SGRSLKGSVF
330
GGWKSRQHIP
340
KLVADYMAEK
350
LNLDPLITHT
360
LNLDKINEAV
ELMKTGKW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0004022 | alcohol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004745 | all-trans-retinol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0042573 | retinoic acid metabolic process |
| Biological Process | GO:0042572 | retinol metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.