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Overview

Uniprot IDP28347
Protein NameTranscriptional enhancer factor TEF-1
Gene NameTEAD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 KSRDFHSKLKDQTAK
57 YPPCGRRKIILSDEG

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif

Protein Sequence

10 MEPSSWSGSE 20 SPAENMERMS 30 DSADKPIDND 40 AEGVWSPDIE 50 QSFQEALAIY 60 PPCGRRKIIL 70 SDEGKMYGRN 80 ELIARYIKLR 90 TGKTRTRKQV 100 SSHIQVLARR 110 KSRDFHSKLK 120 DQTAKDKALQ 130 HMAAMSSAQI 140 VSATAIHNKL 150 GLPGIPRPTF 160 PGAPGFWPGM 170 IQTGQPGSSQ 180 DVKPFVQQAY 190 PIQPAVTAPI 200 PGFEPASAPA 210 PSVPAWQGRS 220 IGTTKLRLVE 230 FSAFLEQQRD 240 PDSYNKHLFV 250 HIGHANHSYS 260 DPLLESVDIR 270 QIYDKFPEKK 280 GGLKELFGKG 290 PQNAFFLVKF 300 WADLNCNIQD 310 DAGAFYGVTS 320 QYESSENMTV 330 TCSTKVCSFG 340 KQVVEKVETE 350 YARFENGRFV 360 YRINRSPMCE 370 YMINFIHKLK 380 HLPEKYMMNS 390 VLENFTILLV 400 VTNRDTQETL 410 LCMACVFEVS 420 NSEHGAQHHI YRLVKD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0140552 TEAD-YAP complex
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0048568 embryonic organ development
Biological Process GO:0035329 hippo signaling
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:1902895 positive regulation of miRNA transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.