Search Results

Overview

Uniprot IDP28370
Protein NameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
Gene NameSMARCA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
59 KGEKKKEKNVSSFQL
67 NVSSFQLKLAAKAPK
71 FQLKLAAKAPKSEKE

Function

ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208)

Protein Sequence

10 MEQDTAAVAA 20 TVAAADATAT 30 IVVIEDEQPG 40 PSTSQEEGAA 50 AAATEATAAT 60 EKGEKKKEKN 70 VSSFQLKLAA 80 KAPKSEKEMD 90 PEYEEKMKAD 100 RAKRFEFLLK 110 QTELFAHFIQ 120 PSAQKSPTSP 130 LNMKLGRPRI 140 KKDEKQSLIS 150 AGDYRHRRTE 160 QEEDEELLSE 170 SRKTSNVCIR 180 FEVSPSYVKG 190 GPLRDYQIRG 200 LNWLISLYEN 210 GVNGILADEM 220 GLGKTLQTIA 230 LLGYLKHYRN 240 IPGPHMVLVP 250 KSTLHNWMNE 260 FKRWVPSLRV 270 ICFVGDKDAR 280 AAFIRDEMMP 290 GEWDVCVTSY 300 EMVIKEKSVF 310 KKFHWRYLVI 320 DEAHRIKNEK 330 SKLSEIVREF 340 KSTNRLLLTG 350 TPLQNNLHEL 360 WALLNFLLPD 370 VFNSADDFDS 380 WFDTKNCLGD 390 QKLVERLHAV 400 LKPFLLRRIK 410 TDVEKSLPPK 420 KEIKIYLGLS 430 KMQREWYTKI 440 LMKDIDVLNS 450 SGKMDKMRLL 460 NILMQLRKCC 470 NHPYLFDGAE 480 PGPPYTTDEH 490 IVSNSGKMVV 500 LDKLLAKLKE 510 QGSRVLIFSQ 520 MTRLLDILED 530 YCMWRGYEYC 540 RLDGQTPHEE 550 REEAIEAFNA 560 PNSSKFIFML 570 STRAGGLGIN 580 LASADVVILY 590 DSDWNPQVDL 600 QAMDRAHRIG 610 QKKPVRVFRL 620 ITDNTVEERI 630 VERAEIKLRL 640 DSIVIQQGRL 650 IDQQSNKLAK 660 EEMLQMIRHG 670 ATHVFASKES 680 ELTDEDITTI 690 LERGEKKTAE 700 MNERLQKMGE 710 SSLRNFRMDI 720 EQSLYKFEGE 730 DYREKQKLGM 740 VEWIEPPKRE 750 RKANYAVDAY 760 FREALRVSEP 770 KIPKAPRPPK 780 QPNVQDFQFF 790 PPRLFELLEK 800 EILYYRKTIG 810 YKVPRNPDIP 820 NPALAQREEQ 830 KKIDGAEPLT 840 PEETEEKEKL 850 LTQGFTNWTK 860 RDFNQFIKAN 870 EKYGRDDIDN 880 IAREVEGKSP 890 EEVMEYSAVF 900 WERCNELQDI 910 EKIMAQIERG 920 EARIQRRISI 930 KKALDAKIAR 940 YKAPFHQLRI 950 QYGTSKGKNY 960 TEEEDRFLIC 970 MLHKMGFDRE 980 NVYEELRQCV 990 RNAPQFRFDW 1000 FIKSRTAMEF 1010 QRRCNTLISL 1020 IEKENMEIEE 1030 RERAEKKKRA 1040 TKTPMVKFSA FS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0090537 CERF complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016589 NURF complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0036310 ATP-dependent DNA/DNA annealing activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0004386 helicase activity
Molecular Function GO:0140750 nucleosome array spacer activity
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process GO:0007420 brain development
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.