Search Results

Overview

Uniprot ID	P28480
Protein Name	T-complex protein 1 subunit alpha
Gene Name	Tcp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
400	HDALCVVKRVLESKS
510	VFEPTIVKVKSLKFA

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia

Protein Sequence

10 MEGPLSVFGD 20 RSTGEAIRSQ 30 NVMAAASIAN 40 IVKSSLGPVG 50 LDKMLVDDIG 60 DVTITNDGAT 70 ILKLLEVEHP 80 AAKVLCELAD 90 LQDKEVGDGT 100 TSVVIIAAEL 110 LKNADELVKQ 120 KIHPTSVISG 130 YRLACKEAVR 140 YINENLIINT 150 DELGRDCLIN 160 AAKTSMSSKI 170 IGINGDFFAN 180 MVVDAVLAVK 190 YTDIRGQPRY 200 PVNSVNILKA 210 HGRSQIESML 220 INGYALNCVV 230 GSQGMLKRIV 240 NAKIACLDFS 250 LQKTKMKLGV 260 QVVITDPEKL 270 DQIRQRESDI 280 TKERIQKILA 290 TGANVILTTG 300 GIDDMCLKYF 310 VEAGAMAVRR 320 VLKRDLKRIA 330 KASGASILST 340 LANLEGEETF 350 EATMLGQAEE 360 VVQERICDDE 370 LILIKNTKAR 380 TSASIILRGA 390 NDFMCDEMER 400 SLHDALCVVK 410 RVLESKSVVP 420 GGGAVEAALS 430 IYLENYATSM 440 GSREQLAIAE 450 FARSLLVIPN 460 TLAVNAAQDS 470 TDLVAKLRAF 480 HNEAQVNPER 490 KNLKWIGLDL 500 VHGKPRDNKQ 510 AGVFEPTIVK 520 VKSLKFATEA 530 AITILRIDDL 540 IKLHPESKDD 550 KHGGYENAVH SGALDD

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:1904851	positive regulation of establishment of protein localization to telomere
Cellular Component	GO:0001669	acrosomal vesicle
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005832	chaperonin-containing T-complex
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000792	heterochromatin
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0000242	pericentriolar material
Cellular Component	GO:0002199	zona pellucida receptor complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0044183	protein folding chaperone
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0007339	binding of sperm to zona pellucida
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase
Biological Process	GO:0006457	protein folding
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0090666	scaRNA localization to Cajal body
Biological Process	GO:0007286	spermatid development

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.