Search Results
Overview
| Uniprot ID | P28491 |
|---|---|
| Protein Name | Calreticulin |
| Gene Name | CALR |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | ICGPGTKKVHVIFNY |
| 151 | VHVIFNYKGKNVLIN |
| 153 | VIFNYKGKNVLINKD |
| 159 | GKNVLINKDIRCKDD |
| 207 | WDFLPPKKIKDPDAV |
| 209 | FLPPKKIKDPDAVKP |
| 215 | IKDPDAVKPEDWDER |
| 224 | EDWDERAKIDDPTDS |
| 238 | SKPEDWDKPEHIPDP |
| 360 | AEKQMKDKQDEEQRL |
| 41 | TDRWIESKHKPDFGR |
| 55 | RFVLSSGKFYGDQEK |
| 62 | KFYGDQEKDKGLQTS |
| 64 | YGDQEKDKGLQTSQD |
Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (PubMed:20222029). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)
Protein Sequence
10
MLLPVPLLLG
20
LVGLAAAEPT
30
IYFKEQFLDG
40
DGWTDRWIES
50
KHKPDFGRFV
60
LSSGKFYGDQ
70
EKDKGLQTSQ
80
DARFYALSAR
90
FEPFSNKGQT
100
LVVQFTVKHE
110
QNIDCGGGYV
120
KLFPDGLDQT
130
DMHGDSEYNI
140
MFGPDICGPG
150
TKKVHVIFNY
160
KGKNVLINKD
170
IRCKDDEFTH
180
LYTLIVRPDN
190
TYEVKIDNSQ
200
VESGSLEDDW
210
DFLPPKKIKD
220
PDAVKPEDWD
230
ERAKIDDPTD
240
SKPEDWDKPE
250
HIPDPDAKKP
260
EDWDEEMDGE
270
WEPPVIQNPE
280
YKGEWKPRQI
290
DNPDYKGTWI
300
HPEIDNPEYS
310
PDSNIYAYEN
320
FAVLGLDLWQ
330
VKSGTIFDNF
340
LITNDEAYAE
350
EFGNETWGVT
360
KAAEKQMKDK
370
QDEEQRLKEE
380
EEEKKRKEEE
390
EVDKEDEEDK
400
DEDEEEEDEK
410
EEEEEEDAAA
GQAKDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0060473 | cortical granule |
| Cellular Component | GO:0044194 | cytolytic granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0044322 | endoplasmic reticulum quality control compartment |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0033018 | sarcoplasmic reticulum lumen |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0001849 | complement component C1q complex binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0005049 | nuclear export signal receptor activity |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway |
| Biological Process | GO:0045665 | negative regulation of neuron differentiation |
| Biological Process | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:1901164 | negative regulation of trophoblast cell migration |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0045787 | positive regulation of cell cycle |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000510 | positive regulation of dendritic cell chemotaxis |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0006611 | protein export from nucleus |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.