Search Results
Overview
| Uniprot ID | P28573 |
|---|---|
| Protein Name | Sodium-dependent proline transporter |
| Gene Name | Slc6a7 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 3 | *****MKKLQEAHLR |
Function
Brain specific sodium (and chloride)-dependent proline transporter (PubMed:10414958). Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable)
Protein Sequence
10
MKKLQEAHLR
20
KPVTPDLLMT
30
PSDQGDVDLD
40
VDFAADRGNW
50
TGKLDFLLSC
60
IGYCVGLGNV
70
WRFPYRAYTN
80
GGGAFLVPYF
90
LMLAICGIPL
100
FFLELSLGQF
110
SSLGPLAVWK
120
ISPLFKGAGA
130
AMLLIVGLVA
140
IYYNMIIAYV
150
LFYLFASLTS
160
NLPWEHCGNW
170
WNTERCLEHR
180
GPKDGNGALP
190
LNLSSTVSPS
200
EEYWSRYVLH
210
IQGSQGIGRP
220
GEIRWNLCLC
230
LLLAWVIVFL
240
CILKGVKSSG
250
KVVYFTATFP
260
YLILLMLLVR
270
GVTLPGAWKG
280
IQFYLTPQFH
290
HLLSSKVWIE
300
AALQIFYSLG
310
VGFGGLLTFA
320
SYNTFHQNIY
330
RDTFIVTLGN
340
AITSILAGFA
350
IFSVLGYMSQ
360
ELGVPVDQVA
370
KAGPGLAFVI
380
YPQAMTMLPL
390
SPFWSFLFFF
400
MLLTLGLDSQ
410
FAFLETIVTA
420
VTDEFPYYLR
430
PKKAVFSGLI
440
CVAMYLMGLI
450
LTTDGGMYWL
460
VLLDDYSASF
470
GLMVVVITTC
480
LAVTRVYGIQ
490
RFCRDIHMML
500
GFKPGLYFRA
510
CWLFLSPATL
520
LALLVYSIVK
530
YQPSEYGSYR
540
FPAWAELLGI
550
LMGLLSCLMI
560
PAGMLVAVLR
570
EEGSLWERLQ
580
QASRPAIDWG
590
PSLEENRTGM
600
YVATLAGSQS
610
PKPLMVHMRK
620
YGGITSFENT
630
AIEVDREIAE
EEEESMM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0015193 | L-proline transmembrane transporter activity |
| Molecular Function | GO:0005298 | proline:sodium symporter activity |
| Biological Process | GO:1903804 | glycine import across plasma membrane |
| Biological Process | GO:0006836 | neurotransmitter transport |
| Biological Process | GO:0035524 | proline transmembrane transport |
| Biological Process | GO:0015824 | proline transport |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.