Search Results
Overview
| Uniprot ID | P28650 |
|---|---|
| Protein Name | Adenylosuccinate synthetase isozyme 1 |
| Gene Name | Adss1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 158 | QRQAQEGKNIGTTKK |
| 18 | PPGTGGVKRGRLQQE |
Function
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Protein Sequence
10
MSGTRASNDR
20
PPGTGGVKRG
30
RLQQEAAATG
40
SRVTVVLGAQ
50
WGDEGKGKVV
60
DLLATDADIV
70
SRCQGGNNAG
80
HTVVVDGKEY
90
DFHLLPSGII
100
NTKAVSFIGN
110
GVVIHLPGLF
120
EEAEKNEKKG
130
LKDWEKRLII
140
SDRAHLVFDF
150
HQAVDGLQEV
160
QRQAQEGKNI
170
GTTKKGIGPT
180
YSSKAARTGL
190
RICDLLSDFD
200
EFSARFKNLA
210
HQHQSMFPTL
220
EIDVEGQLKR
230
LKGFAERIRP
240
MVRDGVYFMY
250
EALHGPPKKV
260
LVEGANAALL
270
DIDFGTYPFV
280
TSSNCTVGGV
290
CTGLGIPPQN
300
IGDVYGVVKA
310
YTTRVGIGAF
320
PTEQINEIGD
330
LLQNRGHEWG
340
VTTGRKRRCG
350
WLDLMILRYA
360
HMVNGFTALA
370
LTKLDILDVL
380
SEIKVGISYK
390
LNGKRIPYFP
400
ANQEILQKVE
410
VEYETLPGWK
420
ADTTGARKWE
430
DLPPQAQSYV
440
RFVENHMGVA
450
VKWVGVGKSR
ESMIQLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Biological Process | GO:0044208 | 'de novo' AMP biosynthetic process |
| Biological Process | GO:0006167 | AMP biosynthetic process |
| Biological Process | GO:0044209 | AMP salvage |
| Biological Process | GO:0006531 | aspartate metabolic process |
| Biological Process | GO:0046040 | IMP metabolic process |
| Biological Process | GO:0006163 | purine nucleotide metabolic process |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0004019 | adenylosuccinate synthase activity |
| Molecular Function | GO:0005525 | GTP binding |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.