Search Results
Overview
| Uniprot ID | P28702 |
|---|---|
| Protein Name | Retinoic acid receptor RXR-beta |
| Gene Name | RXRB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 235 | FFKRTIRKDLTYSCR |
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)
Protein Sequence
10
MSWAARPPFL
20
PQRHAAGQCG
30
PVGVRKEMHC
40
GVASRWRRRR
50
PWLDPAAAAA
60
AAVAGGEQQT
70
PEPEPGEAGR
80
DGMGDSGRDS
90
RSPDSSSPNP
100
LPQGVPPPSP
110
PGPPLPPSTA
120
PSLGGSGAPP
130
PPPMPPPPLG
140
SPFPVISSSM
150
GSPGLPPPAP
160
PGFSGPVSSP
170
QINSTVSLPG
180
GGSGPPEDVK
190
PPVLGVRGLH
200
CPPPPGGPGA
210
GKRLCAICGD
220
RSSGKHYGVY
230
SCEGCKGFFK
240
RTIRKDLTYS
250
CRDNKDCTVD
260
KRQRNRCQYC
270
RYQKCLATGM
280
KREAVQEERQ
290
RGKDKDGDGE
300
GAGGAPEEMP
310
VDRILEAELA
320
VEQKSDQGVE
330
GPGGTGGSGS
340
SPNDPVTNIC
350
QAADKQLFTL
360
VEWAKRIPHF
370
SSLPLDDQVI
380
LLRAGWNELL
390
IASFSHRSID
400
VRDGILLATG
410
LHVHRNSAHS
420
AGVGAIFDRV
430
LTELVSKMRD
440
MRMDKTELGC
450
LRAIILFNPD
460
AKGLSNPSEV
470
EVLREKVYAS
480
LETYCKQKYP
490
EQQGRFAKLL
500
LRLPALRSIG
510
LKCLEHLFFF
520
KLIGDTPIDT
530
FLMEMLEAPH
QLA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0004879 | nuclear receptor activity |
| Molecular Function | GO:0003707 | nuclear steroid receptor activity |
| Molecular Function | GO:0044323 | retinoic acid-responsive element binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071300 | cellular response to retinoic acid |
| Biological Process | GO:0009755 | hormone-mediated signaling pathway |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0030501 | positive regulation of bone mineralization |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048384 | retinoic acid receptor signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.