Search Results
Overview
| Uniprot ID | P28738 |
|---|---|
| Protein Name | Kinesin heavy chain isoform 5C |
| Gene Name | Kif5c |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 775 | KLLLLNDKREQARED |
Function
Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (PubMed:19608740). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity)
Protein Sequence
10
MADPAECSIK
20
VMCRFRPLNE
30
AEILRGDKFI
40
PKFKGEETVV
50
IGQGKPYVFD
60
RVLPPNTTQE
70
QVYNACAKQI
80
VKDVLEGYNG
90
TIFAYGQTSS
100
GKTHTMEGKL
110
HDPQLMGIIP
120
RIAHDIFDHI
130
YSMDENLEFH
140
IKVSYFEIYL
150
DKIRDLLDVS
160
KTNLAVHEDK
170
NRVPYVKGCT
180
ERFVSSPEEV
190
MDVIDEGKAN
200
RHVAVTNMNE
210
HSSRSHSIFL
220
INIKQENVET
230
EKKLSGKLYL
240
VDLAGSEKVS
250
KTGAEGAVLD
260
EAKNINKSLS
270
ALGNVISALA
280
EGTKTHVPYR
290
DSKMTRILQD
300
SLGGNCRTTI
310
VICCSPSVFN
320
EAETKSTLMF
330
GQRAKTIKNT
340
VSVNLELTAE
350
EWKKKYEKEK
360
EKNKALKSVL
370
QHLEMELNRW
380
RNGEAVPEDE
390
QISAKDQKSL
400
EPCDNTPIID
410
NITPVVDGIS
420
AEKEKYDEEI
430
TSLYRQLDDK
440
DDEINQQSQL
450
AEKLKQQMLD
460
QDELLASTRR
470
DYEKIQEELT
480
RLQIENEAAK
490
DEVKEVLQAL
500
EELAVNYDQK
510
SQEVEDKTRA
520
NEQLTDELAQ
530
KTTTLTTTQR
540
ELSQLQELSN
550
HQKKRATEIL
560
NLLLKDLGEI
570
GGIIGTNDVK
580
TLADVNGVIE
590
EEFTMARLYI
600
SKMKSEVKSL
610
VNRSKQLESA
620
QMDSNRKMNA
630
SERELAACQL
640
LISQHEAKIK
650
SLTDYMQNME
660
QKRRQLEESQ
670
DSLSEELAKL
680
RAQEKMHEVS
690
FQDKEKEHLT
700
RLQDAEEVKK
710
ALEQQMESHR
720
EAHQKQLSRL
730
RDEIEEKQRI
740
IDEIRDLNQK
750
LQLEQERLSS
760
DYNKLKIEDQ
770
EREVKLEKLL
780
LLNDKREQAR
790
EDLKGLEETV
800
SRELQTLHNL
810
RKLFVQDLTT
820
RVKKSVELDS
830
DDGGGSAAQK
840
QKISFLENNL
850
EQLTKVHKQL
860
VRDNADLRCE
870
LPKLEKRLRA
880
TAERVKALES
890
ALKEAKENAM
900
RDRKRYQQEV
910
DRIKEAVRAK
920
NMARRAHSAQ
930
IAKPIRPGHY
940
PASSPTAVHA
950
VRGGGGGSSN
STHYQK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0035253 | ciliary rootlet |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0150034 | distal axon |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Molecular Function | GO:0034190 | apolipoprotein receptor binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0003777 | microtubule motor activity |
| Molecular Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Biological Process | GO:0099641 | anterograde axonal protein transport |
| Biological Process | GO:0098964 | anterograde dendritic transport of messenger ribonucleoprotein complex |
| Biological Process | GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0008298 | intracellular mRNA localization |
| Biological Process | GO:0008045 | motor neuron axon guidance |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0048489 | synaptic vesicle transport |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.