Search Results

Overview

Uniprot IDP28749
Protein NameRetinoblastoma-like protein 1
Gene NameRBL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1005 PRSALLYKFNGSPSK
1015 GSPSKSLKDINNMIR

Function

Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904)

Protein Sequence

10 MFEDKPHAEG 20 AAVVAAAGEA 30 LQALCQELNL 40 DEGSAAEALD 50 DFTAIRGNYS 60 LEGEVTHWLA 70 CSLYVACRKS 80 IIPTVGKGIM 90 EGNCVSLTRI 100 LRSAKLSLIQ 110 FFSKMKKWMD 120 MSNLPQEFRE 130 RIERLERNFE 140 VSTVIFKKYE 150 PIFLDIFQNP 160 YEEPPKLPRS 170 RKQRRIPCSV 180 KDLFNFCWTL 190 FVYTKGNFRM 200 IGDDLVNSYH 210 LLLCCLDLIF 220 ANAIMCPNRQ 230 DLLNPSFKGL 240 PSDFHTADFT 250 ASEEPPCIIA 260 VLCELHDGLL 270 VEAKGIKEHY 280 FKPYISKLFD 290 RKILKGECLL 300 DLSSFTDNSK 310 AVNKEYEEYV 320 LTVGDFDERI 330 FLGADAEEEI 340 GTPRKFTRDT 350 PLGKLTAQAN 360 VEYNLQQHFE 370 KKRSFAPSTP 380 LTGRRYLREK 390 EAVITPVASA 400 TQSVSRLQSI 410 VAGLKNAPSD 420 QLINIFESCV 430 RNPVENIMKI 440 LKGIGETFCQ 450 HYTQSTDEQP 460 GSHIDFAVNR 470 LKLAEILYYK 480 ILETVMVQET 490 RRLHGMDMSV 500 LLEQDIFHRS 510 LMACCLEIVL 520 FAYSSPRTFP 530 WIIEVLNLQP 540 FYFYKVIEVV 550 IRSEEGLSRD 560 MVKHLNSIEE 570 QILESLAWSH 580 DSALWEALQV 590 SANKVPTCEE 600 VIFPNNFETG 610 NGGNVQGHLP 620 LMPMSPLMHP 630 RVKEVRTDSG 640 SLRRDMQPLS 650 PISVHERYSS 660 PTAGSAKRRL 670 FGEDPPKEML 680 MDKIITEGTK 690 LKIAPSSSIT 700 AENVSILPGQ 710 TLLTMATAPV 720 TGTTGHKVTI 730 PLHGVANDAG 740 EITLIPLSMN 750 TNQESKVKSP 760 VSLTAHSLIG 770 ASPKQTNLTK 780 AQEVHSTGIN 790 RPKRTGSLAL 800 FYRKVYHLAS 810 VRLRDLCLKL 820 DVSNELRRKI 830 WTCFEFTLVH 840 CPDLMKDRHL 850 DQLLLCAFYI 860 MAKVTKEERT 870 FQEIMKSYRN 880 QPQANSHVYR 890 SVLLKSIPRE 900 VVAYNKNIND 910 DFEMIDCDLE 920 DATKTPDCSS 930 GPVKEERGDL 940 IKFYNTIYVG 950 RVKSFALKYD 960 LANQDHMMDA 970 PPLSPFPHIK 980 QQPGSPRRIS 990 QQHSIYISPH 1000 KNGSGLTPRS 1010 ALLYKFNGSP 1020 SKSLKDINNM 1030 IRQGEQRTKK 1040 RVIAIDSDAE 1050 SPAKRVCQEN 1060 DDVLLKRLQD VVSERANH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:2000773 negative regulation of cellular senescence
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0043550 regulation of lipid kinase activity
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.