Search Results

Overview

Uniprot ID	P28827
Protein Name	Receptor-type tyrosine-protein phosphatase mu
Gene Name	PTPRM
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
926	KKDENRMKNRYGNII

Function

Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202)

Protein Sequence

10 MRGLGTCLAT 20 LAGLLLTAAG 30 ETFSGGCLFD 40 EPYSTCGYSQ 50 SEGDDFNWEQ 60 VNTLTKPTSD 70 PWMPSGSFML 80 VNASGRPEGQ 90 RAHLLLPQLK 100 ENDTHCIDFH 110 YFVSSKSNSP 120 PGLLNVYVKV 130 NNGPLGNPIW 140 NISGDPTRTW 150 NRAELAISTF 160 WPNFYQVIFE 170 VITSGHQGYL 180 AIDEVKVLGH 190 PCTRTPHFLR 200 IQNVEVNAGQ 210 FATFQCSAIG 220 RTVAGDRLWL 230 QGIDVRDAPL 240 KEIKVTSSRR 250 FIASFNVVNT 260 TKRDAGKYRC 270 MIRTEGGVGI 280 SNYAELVVKE 290 PPVPIAPPQL 300 ASVGATYLWI 310 QLNANSINGD 320 GPIVAREVEY 330 CTASGSWNDR 340 QPVDSTSYKI 350 GHLDPDTEYE 360 ISVLLTRPGE 370 GGTGSPGPAL 380 RTRTKCADPM 390 RGPRKLEVVE 400 VKSRQITIRW 410 EPFGYNVTRC 420 HSYNLTVHYC 430 YQVGGQEQVR 440 EEVSWDTENS 450 HPQHTITNLS 460 PYTNVSVKLI 470 LMNPEGRKES 480 QELIVQTDED 490 LPGAVPTESI 500 QGSTFEEKIF 510 LQWREPTQTY 520 GVITLYEITY 530 KAVSSFDPEI 540 DLSNQSGRVS 550 KLGNETHFLF 560 FGLYPGTTYS 570 FTIRASTAKG 580 FGPPATNQFT 590 TKISAPSMPA 600 YELETPLNQT 610 DNTVTVMLKP 620 AHSRGAPVSV 630 YQIVVEEERP 640 RRTKKTTEIL 650 KCYPVPIHFQ 660 NASLLNSQYY 670 FAAEFPADSL 680 QAAQPFTIGD 690 NKTYNGYWNT 700 PLLPYKSYRI 710 YFQAASRANG 720 ETKIDCVQVA 730 TKGAATPKPV 740 PEPEKQTDHT 750 VKIAGVIAGI 760 LLFVIIFLGV 770 VLVMKKRKLA 780 KKRKETMSST 790 RQEMTVMVNS 800 MDKSYAEQGT 810 NCDEAFSFMD 820 THNLNGRSVS 830 SPSSFTMKTN 840 TLSTSVPNSY 850 YPDETHTMAS 860 DTSSLVQSHT 870 YKKREPADVP 880 YQTGQLHPAI 890 RVADLLQHIT 900 QMKCAEGYGF 910 KEEYESFFEG 920 QSAPWDSAKK 930 DENRMKNRYG 940 NIIAYDHSRV 950 RLQTIEGDTN 960 SDYINGNYID 970 GYHRPNHYIA 980 TQGPMQETIY 990 DFWRMVWHEN 1000 TASIIMVTNL 1010 VEVGRVKCCK 1020 YWPDDTEIYK 1030 DIKVTLIETE 1040 LLAEYVIRTF 1050 AVEKRGVHEI 1060 REIRQFHFTG 1070 WPDHGVPYHA 1080 TGLLGFVRQV 1090 KSKSPPSAGP 1100 LVVHCSAGAG 1110 RTGCFIVIDI 1120 MLDMAEREGV 1130 VDIYNCVREL 1140 RSRRVNMVQT 1150 EEQYVFIHDA 1160 ILEACLCGDT 1170 SVPASQVRSL 1180 YYDMNKLDPQ 1190 TNSSQIKEEF 1200 RTLNMVTPTL 1210 RVEDCSIALL 1220 PRNHEKNRCM 1230 DILPPDRCLP 1240 FLITIDGESS 1250 NYINAALMDS 1260 YKQPSAFIVT 1270 QHPLPNTVKD 1280 FWRLVLDYHC 1290 TSVVMLNDVD 1300 PAQLCPQYWP 1310 ENGVHRHGPI 1320 QVEFVSADLE 1330 EDIISRIFRI 1340 YNAARPQDGY 1350 RMVQQFQFLG 1360 WPMYRDTPVS 1370 KRSFLKLIRQ 1380 VDKWQEEYNG 1390 GEGRTVVHCL 1400 NGGGRSGTFC 1410 AISIVCEMLR 1420 HQRTVDVFHA 1430 VKTLRNNKPN 1440 MVDLLDQYKF 1450 CYEVALEYLN SG

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0007156	homophilic cell-cell adhesion
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0016791	phosphatase activity
Molecular Function	GO:0004725	protein tyrosine phosphatase activity
Molecular Function	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0010596	negative regulation of endothelial cell migration
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation
Biological Process	GO:0031175	neuron projection development
Biological Process	GO:0010828	positive regulation of D-glucose transmembrane transport
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0010842	retina layer formation
Biological Process	GO:0031290	retinal ganglion cell axon guidance
Biological Process	GO:0007165	signal transduction

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.