Search Results
Overview
| Uniprot ID | P28839 |
|---|---|
| Protein Name | Cytosol aminopeptidase |
| Gene Name | LAP3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | DELKQKKKVVVSAKL |
| 79 | NISGPPLKAGKTRTF |
Function
Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Protein Sequence
10
MFLLPLPAAA
20
RVAVRQLSVR
30
RFWGPGPDAA
40
NMTKGLVLGI
50
YSKEKEDDAP
60
QFTSAGENFD
70
KLVSGKLREI
80
LNISGPPLKA
90
GKTRTFYGLH
100
EDFSSVVVVG
110
LGKKGAGVDD
120
QENWHEGKEN
130
IRAAVAAGCR
140
QIQDLEIPSV
150
EVDPCGDAQA
160
AAEGAVLGLY
170
EYDELKQKKK
180
VVVSAKLHGS
190
GDQEAWQRGV
200
LFASGQNLAR
210
HLMETPANEM
220
TPTRFAEVIE
230
KNLKSASSKT
240
DVHIRPKSWI
250
EEQEMGSFLS
260
VAKGSEEPPV
270
FLEIHYKGSP
280
DASDPPLVFV
290
GKGITFDSGG
300
ISIKASANMD
310
LMRADMGGAA
320
TICSTIVSAA
330
KLDLPINLVG
340
LAPLCENMPS
350
GKANKPGDVV
360
RAKNGKTIQV
370
DNTDAEGRLI
380
LADALCYAHT
390
FNPKVIINAA
400
TLTGAMDIAL
410
GSGATGVFTN
420
SSWLWNKLFE
430
ASIETGDRVW
440
RMPLFEHYTK
450
QIVDCQLADV
460
NNIGKYRSAG
470
ACTAAAFLKE
480
FVTHPKWAHL
490
DIAGVMTNKD
500
EVPYLRKGMA
510
GRPTRTLIEF
LLRFSQDSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.