Search Results
Overview
| Uniprot ID | P29083 |
|---|---|
| Protein Name | General transcription factor IIE subunit 1 |
| Gene Name | GTF2E1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 330 | RALLIHEKKTSSAMA |
| 331 | ALLIHEKKTSSAMAG |
Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase
Protein Sequence
10
MADPDVLTEV
20
PAALKRLAKY
30
VIRGFYGIEH
40
ALALDILIRN
50
SCVKEEDMLE
60
LLKFDRKQLR
70
SVLNNLKGDK
80
FIKCRMRVET
90
AADGKTTRHN
100
YYFINYRTLV
110
NVVKYKLDHM
120
RRRIETDERD
130
STNRASFKCP
140
VCSSTFTDLE
150
ANQLFDPMTG
160
TFRCTFCHTE
170
VEEDESAMPK
180
KDARTLLARF
190
NEQIEPIYAL
200
LRETEDVNLA
210
YEILEPEPTE
220
IPALKQSKDH
230
AATTAGAASL
240
AGGHHREAWA
250
TKGPSYEDLY
260
TQNVVINMDD
270
QEDLHRASLE
280
GKSAKERPIW
290
LRESTVQGAY
300
GSEDMKEGGI
310
DMDAFQEREE
320
GHAGPDDNEE
330
VMRALLIHEK
340
KTSSAMAGSV
350
GAAAPVTAAN
360
GSDSESETSE
370
SDDDSPPRPA
380
AVAVHKREED
390
EEEDDEFEEV
400
ADDPIVMVAG
410
RPFSYSEVSQ
420
RPELVAQMTP
430
EEKEAYIAMG
QRMFEDLFE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005669 | transcription factor TFIID complex |
| Cellular Component | GO:0005673 | transcription factor TFIIE complex |
| Molecular Function | GO:0016251 | RNA polymerase II general transcription initiation factor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.