Search Results

Overview

Uniprot IDP29084
Protein NameTranscription initiation factor IIE subunit beta
Gene NameGTF2E2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
197 LFVNRPDKKKILFFN
24 LSTPVVEKRSASSES
252 MQESGPKKVAPIQRR
271 SQKKRRFKTHNEHLA
42 SSKKKKTKVEHGGSS
74 LSGSSGYKFGVLAKI

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Protein Sequence

10 MDPSLLRERE 20 LFKKRALSTP 30 VVEKRSASSE 40 SSSSSSKKKK 50 TKVEHGGSSG 60 SKQNSDHSNG 70 SFNLKALSGS 80 SGYKFGVLAK 90 IVNYMKTRHQ 100 RGDTHPLTLD 110 EILDETQHLD 120 IGLKQKQWLM 130 TEALVNNPKI 140 EVIDGKYAFK 150 PKYNVRDKKA 160 LLRLLDQHDQ 170 RGLGGILLED 180 IEEALPNSQK 190 AVKALGDQIL 200 FVNRPDKKKI 210 LFFNDKSCQF 220 SVDEEFQKLW 230 RSVTVDSMDE 240 EKIEEYLKRQ 250 GISSMQESGP 260 KKVAPIQRRK 270 KPASQKKRRF 280 KTHNEHLAGV 290 LKDYSDITSS K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005669 transcription factor TFIID complex
Cellular Component GO:0005673 transcription factor TFIIE complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0016251 RNA polymerase II general transcription initiation factor activity
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.