Search Results
Overview
| Uniprot ID | P29101 |
|---|---|
| Protein Name | Synaptotagmin-2 |
| Gene Name | Syt2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 237 | YDFDRFSKHDIIGEV |
Function
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes
Protein Sequence
10
MRNIFKRNQE
20
PIVAPATTTA
30
TMPLAPAAPA
40
DNSTESTGTG
50
ESQEDMFAKL
60
KDKFFNEINK
70
IPLPPWALIA
80
MAVVAGLLLL
90
TCCFCICKKC
100
CCKKKKNKKE
110
KGKGMKNAMN
120
MKDMKGGQDD
130
DDAETGLTEG
140
EGEGEEEKEP
150
ENLGKLQFSL
160
DYDFQANQLT
170
VGVLQAAELP
180
ALDMGGTSDP
190
YVKVFLLPDK
200
KKKYETKVHR
210
KTLNPAFNET
220
FTFKVPYQEL
230
GGKTLVMAIY
240
DFDRFSKHDI
250
IGEVKVPMNT
260
VDLGQPIEEW
270
RDLQGGEKEE
280
PEKLGDICTS
290
LRYVPTAGKL
300
TVCILEAKNL
310
KKMDVGGLSD
320
PYVKIHLMQN
330
GKRLKKKKTT
340
VKKKTLNPYF
350
NESFSFEIPF
360
EQIQKVQVVV
370
TVLDYDKLGK
380
NEAIGKIFVG
390
SNATGTELRH
400
WSDMLANPRR
410
PIAQWHSLKP
420
EEEVDALLGK
NK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0042584 | chromaffin granule membrane |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0070382 | exocytic vesicle |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061891 | calcium ion sensor activity |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Biological Process | GO:0099502 | calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0017158 | regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.