Overview
| Uniprot ID | P29117 |
|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
|---|
| Gene Name | Ppif |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 189 |
KIESFGSKSGKTSKK |
| 72 |
LKADVVPKTAENFRA |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:8567677, PubMed:9309684, PubMed:9820802). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:8567677, PubMed:9309684, PubMed:9820802). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:8567677, PubMed:9309684, PubMed:9820802). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed:8567677, PubMed:9309684, PubMed:9820802). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691)
Protein Sequence
10
MLALRCGPRL
20
LGLLSGPRSA
30
PLLLSTTRTC
40
SDGGARGANS
50
SSQNPLVYLD
60
VGADGQPLGR
70
VVLELKADVV
80
PKTAENFRAL
90
CTGEKGFGYK
100
GSTFHRVIPA
110
FMCQAGDFTN
120
HNGTGGKSIY
130
GSRFPDENFT
140
LKHVGPGVLS
150
MANAGPNTNG
160
SQFFICTIKT
170
DWLDGKHVVF
180
GHVKEGMDVV
190
KKIESFGSKS
200
GKTSKKIVIT
DCGQLS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005757 |
mitochondrial permeability transition pore complex |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0016018 |
cyclosporin A binding |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0042277 |
peptide binding |
| Molecular Function |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
| Biological Process |
GO:0008637 |
apoptotic mitochondrial changes |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0071243 |
cellular response to arsenic-containing substance |
| Biological Process |
GO:0071277 |
cellular response to calcium ion |
| Biological Process |
GO:0070301 |
cellular response to hydrogen peroxide |
| Biological Process |
GO:0051882 |
mitochondrial depolarization |
| Biological Process |
GO:1902686 |
mitochondrial outer membrane permeabilization involved in programmed cell death |
| Biological Process |
GO:0007005 |
mitochondrion organization |
| Biological Process |
GO:0061061 |
muscle structure development |
| Biological Process |
GO:0070266 |
necroptotic process |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
| Biological Process |
GO:0090324 |
negative regulation of oxidative phosphorylation |
| Biological Process |
GO:0090201 |
negative regulation of release of cytochrome c from mitochondria |
| Biological Process |
GO:0012501 |
programmed cell death |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0046902 |
regulation of mitochondrial membrane permeability |
| Biological Process |
GO:1902445 |
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
| Biological Process |
GO:0002931 |
response to ischemia |
| Biological Process |
GO:0006979 |
response to oxidative stress |
| Biological Process |
GO:0098528 |
skeletal muscle fiber differentiation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.