Search Results

Overview

Uniprot IDP29144
Protein NameTripeptidyl-peptidase 2
Gene NameTPP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
715 KFCSLPEKGTLTEAF

Function

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity)

Protein Sequence

10 MATAATEEPF 20 PFHGLLPKKE 30 TGAASFLCRY 40 PEYDGRGVLI 50 AVLDTGVDPG 60 APGMQVTTDG 70 KPKIVDIIDT 80 TGSGDVNTAT 90 EVEPKDGEIV 100 GLSGRVLKIP 110 ASWTNPSGKY 120 HIGIKNGYDF 130 YPKALKERIQ 140 KERKEKIWDP 150 VHRVALAEAC 160 RKQEEFDVAN 170 NGSSQANKLI 180 KEELQSQVEL 190 LNSFEKKYSD 200 PGPVYDCLVW 210 HDGEVWRACI 220 DSNEDGDLSK 230 STVLRNYKEA 240 QEYGSFGTAE 250 MLNYSVNIYD 260 DGNLLSIVTS 270 GGAHGTHVAS 280 IAAGHFPEEP 290 ERNGVAPGAQ 300 ILSIKIGDTR 310 LSTMETGTGL 320 IRAMIEVINH 330 KCDLVNYSYG 340 EATHWPNSGR 350 ICEVINEAVW 360 KHNIIYVSSA 370 GNNGPCLSTV 380 GCPGGTTSSV 390 IGVGAYVSPD 400 MMVAEYSLRE 410 KLPANQYTWS 420 SRGPSADGAL 430 GVSISAPGGA 440 IASVPNWTLR 450 GTQLMNGTSM 460 SSPNACGGIA 470 LILSGLKANN 480 IDYTVHSVRR 490 ALENTAVKAD 500 NIEVFAQGHG 510 IIQVDKAYDY 520 LVQNTSFANK 530 LGFTVTVGNN 540 RGIYLRDPVQ 550 VAAPSDHGVG 560 IEPVFPENTE 570 NSEKISLQLH 580 LALTSNSSWV 590 QCPSHLELMN 600 QCRHINIRVD 610 PRGLREGLHY 620 TEVCGYDIAS 630 PNAGPLFRVP 640 ITAVIAAKVN 650 ESSHYDLAFT 660 DVHFKPGQIR 670 RHFIEVPEGA 680 TWAEVTVCSC 690 SSEVSAKFVL 700 HAVQLVKQRA 710 YRSHEFYKFC 720 SLPEKGTLTE 730 AFPVLGGKAI 740 EFCIARWWAS 750 LSDVNIDYTI 760 SFHGIVCTAP 770 QLNIHASEGI 780 NRFDVQSSLK 790 YEDLAPCITL 800 KNWVQTLRPV 810 SAKTKPLGSR 820 DVLPNNRQLY 830 EMVLTYNFHQ 840 PKSGEVTPSC 850 PLLCELLYES 860 EFDSQLWIIF 870 DQNKRQMGSG 880 DAYPHQYSLK 890 LEKGDYTIRL 900 QIRHEQISDL 910 ERLKDLPFIV 920 SHRLSNTLSL 930 DIHENHSFAL 940 LGKKKSSNLT 950 LPPKYNQPFF 960 VTSLPDDKIP 970 KGAGPGCYLA 980 GSLTLSKTEL 990 GKKADVIPVH 1000 YYLIPPPTKT 1010 KNGSKDKEKD 1020 SEKEKDLKEE 1030 FTEALRDLKI 1040 QWMTKLDSSD 1050 IYNELKETYP 1060 NYLPLYVARL 1070 HQLDAEKERM 1080 KRLNEIVDAA 1090 NAVISHIDQT 1100 ALAVYIAMKT 1110 DPRPDAATIK 1120 NDMDKQKSTL 1130 VDALCRKGCA 1140 LADHLLHTQA 1150 QDGAISTDAE 1160 GKEEEGESPL 1170 DSLAETFWET 1180 TKWTDLFDNK 1190 VLTFAYKHAL 1200 VNKMYGRGLK 1210 FATKLVEEKP 1220 TKENWKNCIQ 1230 LMKLLGWTHC 1240 ASFTENWLPI MYPPDYCVF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016604 nuclear body
Molecular Function GO:0004177 aminopeptidase activity
Molecular Function GO:0004175 endopeptidase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004252 serine-type endopeptidase activity
Molecular Function GO:0008240 tripeptidyl-peptidase activity
Biological Process GO:0080144 intracellular amino acid homeostasis
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006508 proteolysis

Reference

PMID: N/A