Overview
| Uniprot ID | P29218 |
|---|
| Protein Name | Inositol monophosphatase 1 |
|---|
| Gene Name | IMPA1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 61 |
LISSIKEKYPSHSFI |
Function
Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol (PubMed:17068342, PubMed:8718889, PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (PubMed:17068342). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:17068342, PubMed:8718889, PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function (PubMed:26416544, PubMed:8718889). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder (PubMed:17068342). Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate (PubMed:9462881)
Protein Sequence
10
MADPWQECMD
20
YAVTLARQAG
30
EVVCEAIKNE
40
MNVMLKSSPV
50
DLVTATDQKV
60
EKMLISSIKE
70
KYPSHSFIGE
80
ESVAAGEKSI
90
LTDNPTWIID
100
PIDGTTNFVH
110
RFPFVAVSIG
120
FAVNKKIEFG
130
VVYSCVEGKM
140
YTARKGKGAF
150
CNGQKLQVSQ
160
QEDITKSLLV
170
TELGSSRTPE
180
TVRMVLSNME
190
KLFCIPVHGI
200
RSVGTAAVNM
210
CLVATGGADA
220
YYEMGIHCWD
230
VAGAGIIVTE
240
AGGVLMDVTG
250
GPFDLMSRRV
260
IAANNRILAE
270
RIAKEIQVIP
LQRDDED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0103026 |
fructose-1-phosphatase activity |
| Molecular Function |
GO:0008877 |
glucose-1-phosphatase activity |
| Molecular Function |
GO:0004346 |
glucose-6-phosphatase activity |
| Molecular Function |
GO:0047954 |
glycerol-2-phosphatase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008934 |
inositol monophosphate 1-phosphatase activity |
| Molecular Function |
GO:0052832 |
inositol monophosphate 3-phosphatase activity |
| Molecular Function |
GO:0052833 |
inositol monophosphate 4-phosphatase activity |
| Molecular Function |
GO:0052834 |
inositol monophosphate phosphatase activity |
| Molecular Function |
GO:0031403 |
lithium ion binding |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0030145 |
manganese ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006021 |
inositol biosynthetic process |
| Biological Process |
GO:0006020 |
inositol metabolic process |
| Biological Process |
GO:0006796 |
phosphate-containing compound metabolic process |
| Biological Process |
GO:0006661 |
phosphatidylinositol biosynthetic process |
| Biological Process |
GO:0046854 |
phosphatidylinositol phosphate biosynthetic process |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.