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Overview

Uniprot IDP29314
Protein NameSmall ribosomal subunit protein uS4
Gene NameRps9
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
11 ARSWVCRKTYVTPRR
139 QRHIRVRKQVVNIPS
155 IVRLDSQKHIDFSLR
47 KREVWRVKFTLAKIR
66 ELLTLDEKDPRRLFE
91 IGVLDEGKMKLDYIL
93 VLDEGKMKLDYILGL

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MPVARSWVCR 20 KTYVTPRRPF 30 EKSRLDQELK 40 LIGEYGLRNK 50 REVWRVKFTL 60 AKIRKAAREL 70 LTLDEKDPRR 80 LFEGNALLRR 90 LVRIGVLDEG 100 KMKLDYILGL 110 KIEDFLERRL 120 QTQVFKLGLA 130 KSIHHARVLI 140 RQRHIRVRKQ 150 VVNIPSFIVR 160 LDSQKHIDFS 170 LRSPYGGGRP 180 GRVKRKNAKK 190 GQGGAGAGDD EEED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0022627 cytosolic small ribosomal subunit
Cellular Component GO:0005730 nucleolus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0032040 small-subunit processome
Cellular Component GO:0045202 synapse
Molecular Function GO:1990932 5.8S rRNA binding
Molecular Function GO:0019843 rRNA binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:0042274 ribosomal small subunit biogenesis

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.