Search Results
Overview
| Uniprot ID | P29350 |
|---|---|
| Protein Name | Tyrosine-protein phosphatase non-receptor type 6 |
| Gene Name | PTPN6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 560 | SRTSSKHKEDVYENL |
Function
Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042105 | alpha-beta T cell receptor complex |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0140031 | phosphorylation-dependent protein binding |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| Biological Process | GO:0160162 | CD27 signaling pathway |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:1905867 | epididymis development |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0050859 | negative regulation of B cell receptor signaling pathway |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0106015 | negative regulation of inflammatory response to wounding |
| Biological Process | GO:0045824 | negative regulation of innate immune response |
| Biological Process | GO:0032715 | negative regulation of interleukin-6 production |
| Biological Process | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:0033007 | negative regulation of mast cell activation involved in immune response |
| Biological Process | GO:1902564 | negative regulation of neutrophil activation |
| Biological Process | GO:0032720 | negative regulation of tumor necrosis factor production |
| Biological Process | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| Biological Process | GO:0018108 | peptidyl-tyrosine phosphorylation |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0060338 | regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:0042110 | T cell activation |
| Biological Process | GO:0031295 | T cell costimulation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.