Overview
| Uniprot ID | P29353 |
|---|
| Protein Name | SHC-transforming protein 1 |
|---|
| Gene Name | SHC1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 321 |
QYLRNPPKLVTPHDR |
| 9 |
DLLPPKPKYNPLRNE |
Function
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (PubMed:11016927)
Protein Sequence
10
MDLLPPKPKY
20
NPLRNESLSS
30
LEEGASGSTP
40
PEELPSPSAS
50
SLGPILPPLP
60
GDDSPTTLCS
70
FFPRMSNLRL
80
ANPAGGRPGS
90
KGEPGRAADD
100
GEGIVGAAMP
110
DSGPLPLLQD
120
MNKLSGGGGR
130
RTRVEGGQLG
140
GEEWTRHGSF
150
VNKPTRGWLH
160
PNDKVMGPGV
170
SYLVRYMGCV
180
EVLQSMRALD
190
FNTRTQVTRE
200
AISLVCEAVP
210
GAKGATRRRK
220
PCSRPLSSIL
230
GRSNLKFAGM
240
PITLTVSTSS
250
LNLMAADCKQ
260
IIANHHMQSI
270
SFASGGDPDT
280
AEYVAYVAKD
290
PVNQRACHIL
300
ECPEGLAQDV
310
ISTIGQAFEL
320
RFKQYLRNPP
330
KLVTPHDRMA
340
GFDGSAWDEE
350
EEEPPDHQYY
360
NDFPGKEPPL
370
GGVVDMRLRE
380
GAAPGAARPT
390
APNAQTPSHL
400
GATLPVGQPV
410
GGDPEVRKQM
420
PPPPPCPGRE
430
LFDDPSYVNV
440
QNLDKARQAV
450
GGAGPPNPAI
460
NGSAPRDLFD
470
MKPFEDALRV
480
PPPPQSVSMA
490
EQLRGEPWFH
500
GKLSRREAEA
510
LLQLNGDFLV
520
RESTTTPGQY
530
VLTGLQSGQP
540
KHLLLVDPEG
550
VVRTKDHRFE
560
SVSHLISYHM
570
DNHLPIISAG
580
SELCLQQPVE
RKL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0070435 |
Shc-EGFR complex |
| Molecular Function |
GO:0046875 |
ephrin receptor binding |
| Molecular Function |
GO:0048408 |
epidermal growth factor binding |
| Molecular Function |
GO:0005154 |
epidermal growth factor receptor binding |
| Molecular Function |
GO:0005158 |
insulin receptor binding |
| Molecular Function |
GO:0005159 |
insulin-like growth factor receptor binding |
| Molecular Function |
GO:0005168 |
neurotrophin TRKA receptor binding |
| Molecular Function |
GO:0005543 |
phospholipid binding |
| Molecular Function |
GO:0001784 |
phosphotyrosine residue binding |
| Molecular Function |
GO:0030971 |
receptor tyrosine kinase binding |
| Molecular Function |
GO:0005068 |
transmembrane receptor protein tyrosine kinase adaptor activity |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0071363 |
cellular response to growth factor stimulus |
| Biological Process |
GO:0042742 |
defense response to bacterium |
| Biological Process |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
| Biological Process |
GO:0008286 |
insulin receptor signaling pathway |
| Biological Process |
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0016525 |
negative regulation of angiogenesis |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0071864 |
positive regulation of cell proliferation in bone marrow |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0043410 |
positive regulation of MAPK cascade |
| Biological Process |
GO:0090322 |
regulation of superoxide metabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.