Search Results
Overview
| Uniprot ID | P29372 |
|---|---|
| Protein Name | DNA-3-methyladenine glycosylase |
| Gene Name | MPG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 80 | SIYFSSPKGHLTRLG |
Function
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions
Protein Sequence
10
MVTPALQMKK
20
PKQFCRRMGQ
30
KKQRPARAGQ
40
PHSSSDAAQA
50
PAEQPHSSSD
60
AAQAPCPRER
70
CLGPPTTPGP
80
YRSIYFSSPK
90
GHLTRLGLEF
100
FDQPAVPLAR
110
AFLGQVLVRR
120
LPNGTELRGR
130
IVETEAYLGP
140
EDEAAHSRGG
150
RQTPRNRGMF
160
MKPGTLYVYI
170
IYGMYFCMNI
180
SSQGDGACVL
190
LRALEPLEGL
200
ETMRQLRSTL
210
RKGTASRVLK
220
DRELCSGPSK
230
LCQALAINKS
240
FDQRDLAQDE
250
AVWLERGPLE
260
PSEPAVVAAA
270
RVGVGHAGEW
280
ARKPLRFYVR
290
GSPWVSVVDR
VAEQDTQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0045007 | depurination |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003905 | alkylbase DNA N-glycosylase activity |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0019104 | DNA N-glycosylase activity |
| Biological Process | GO:0006284 | base-excision repair |
| Biological Process | GO:0006307 | DNA alkylation repair |
Reference
PMID: N/A