Search Results
Overview
| Uniprot ID | P29411 |
|---|---|
| Protein Name | GTP:AMP phosphotransferase AK3, mitochondrial |
| Gene Name | Ak3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 29 | TGSSRITKHFELKHL |
Function
Mitochondrial adenylate kinase with a specific GTP:AMP phosphotransferase activity. Could also use ITP as phosphate donor. Its physiological function is to recycle GTP into GDP which is necessary for the TCA cycle in the mitochondrial matrix
Protein Sequence
10
MGASGRLLRA
20
VIMGAPGSGK
30
GTGSSRITKH
40
FELKHLSSGD
50
LLRQNMLQGT
60
EIAVLAKSFI
70
DQGKLIPDDD
80
MTRLALHELK
90
NLTQCSWLLD
100
GFPRTLPQAE
110
ALDRVYQIDT
120
VINLNVPFEV
130
IKLRLTARWI
140
HPASGRVYNI
150
EFNPPKTVGI
160
DDLTGEPLIQ
170
REDDKPETVI
180
KRLKAYEAQT
190
EPVLQYYQKK
200
GVLETFSGTE
210
TNKIRPHVYS
220
FLQMKVPETI
QKASVTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0046051 | UTP metabolic process |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004017 | AMP kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046899 | nucleoside triphosphate adenylate kinase activity |
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0006756 | AMP phosphorylation |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0046060 | dATP metabolic process |
| Biological Process | GO:0046039 | GTP metabolic process |
| Biological Process | GO:0046041 | ITP metabolic process |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0007517 | muscle organ development |
| Biological Process | GO:0009142 | nucleoside triphosphate biosynthetic process |
| Biological Process | GO:0021772 | olfactory bulb development |
| Biological Process | GO:0042594 | response to starvation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.