Search Results
Overview
| Uniprot ID | P29457 |
|---|---|
| Protein Name | Serpin H1 |
| Gene Name | Serpinh1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | KAVLSAEKLRDEEVH |
| 189 | GKLPEVTKDVERTDG |
| 212 | FKPHWDEKFHHKMVD |
| 216 | WDEKFHHKMVDNRGF |
| 22 | ALAAEVKKPVEAAAP |
| 251 | YYDDEKEKLQLVEMP |
| 282 | EPLERLEKLLTKEQL |
| 286 | RLEKLLTKEQLKTWM |
| 290 | LLTKEQLKTWMGKMQ |
| 295 | QLKTWMGKMQKKAVA |
| 299 | WMGKMQKKAVAISLP |
| 307 | AVAISLPKGVVEVTH |
| 333 | TEAIDKNKADLSRMS |
| 34 | AAPGTAEKLSSKATT |
| 379 | REELRSPKLFYADHP |
| 38 | TAEKLSSKATTLAER |
| 93 | ATTASQAKAVLSAEK |
Function
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen
Protein Sequence
10
MRSLLLGTLC
20
LLAVALAAEV
30
KKPVEAAAPG
40
TAEKLSSKAT
50
TLAERSTGLA
60
FSLYQAMAKD
70
QAVENILLSP
80
LVVASSLGLV
90
SLGGKATTAS
100
QAKAVLSAEK
110
LRDEEVHTGL
120
GELVRSLSNS
130
TARNVTWKLG
140
SRLYGPSSVS
150
FADDFVRSSK
160
QHYNCEHSKI
170
NFRDKRSALQ
180
SINEWASQTT
190
DGKLPEVTKD
200
VERTDGALLV
210
NAMFFKPHWD
220
EKFHHKMVDN
230
RGFMVTRSYT
240
VGVTMMHRTG
250
LYNYYDDEKE
260
KLQLVEMPLA
270
HKLSSLIILM
280
PHHVEPLERL
290
EKLLTKEQLK
300
TWMGKMQKKA
310
VAISLPKGVV
320
EVTHDLQKHL
330
AGLGLTEAID
340
KNKADLSRMS
350
GKKDLYLASV
360
FHATAFEWDT
370
EGNPFDQDIY
380
GREELRSPKL
390
FYADHPFIFL
400
VRDNQSGSLL
410
FIGRLVRPKG
DKMRDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0005518 | collagen binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0045121 | membrane raft |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis |
| Biological Process | GO:0032964 | collagen biosynthetic process |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.