Search Results
Overview
| Uniprot ID | P29475 |
|---|---|
| Protein Name | Nitric oxide synthase 1 |
| Gene Name | NOS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 783 | KTLCEIFKHAFDAKV |
Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR
Protein Sequence
10
MEDHMFGVQQ
20
IQPNVISVRL
30
FKRKVGGLGF
40
LVKERVSKPP
50
VIISDLIRGG
60
AAEQSGLIQA
70
GDIILAVNGR
80
PLVDLSYDSA
90
LEVLRGIASE
100
THVVLILRGP
110
EGFTTHLETT
120
FTGDGTPKTI
130
RVTQPLGPPT
140
KAVDLSHQPP
150
AGKEQPLAVD
160
GASGPGNGPQ
170
HAYDDGQEAG
180
SLPHANGLAP
190
RPPGQDPAKK
200
ATRVSLQGRG
210
ENNELLKEIE
220
PVLSLLTSGS
230
RGVKGGAPAK
240
AEMKDMGIQV
250
DRDLDGKSHK
260
PLPLGVENDR
270
VFNDLWGKGN
280
VPVVLNNPYS
290
EKEQPPTSGK
300
QSPTKNGSPS
310
KCPRFLKVKN
320
WETEVVLTDT
330
LHLKSTLETG
340
CTEYICMGSI
350
MHPSQHARRP
360
EDVRTKGQLF
370
PLAKEFIDQY
380
YSSIKRFGSK
390
AHMERLEEVN
400
KEIDTTSTYQ
410
LKDTELIYGA
420
KHAWRNASRC
430
VGRIQWSKLQ
440
VFDARDCTTA
450
HGMFNYICNH
460
VKYATNKGNL
470
RSAITIFPQR
480
TDGKHDFRVW
490
NSQLIRYAGY
500
KQPDGSTLGD
510
PANVQFTEIC
520
IQQGWKPPRG
530
RFDVLPLLLQ
540
ANGNDPELFQ
550
IPPELVLEVP
560
IRHPKFEWFK
570
DLGLKWYGLP
580
AVSNMLLEIG
590
GLEFSACPFS
600
GWYMGTEIGV
610
RDYCDNSRYN
620
ILEEVAKKMN
630
LDMRKTSSLW
640
KDQALVEINI
650
AVLYSFQSDK
660
VTIVDHHSAT
670
ESFIKHMENE
680
YRCRGGCPAD
690
WVWIVPPMSG
700
SITPVFHQEM
710
LNYRLTPSFE
720
YQPDPWNTHV
730
WKGTNGTPTK
740
RRAIGFKKLA
750
EAVKFSAKLM
760
GQAMAKRVKA
770
TILYATETGK
780
SQAYAKTLCE
790
IFKHAFDAKV
800
MSMEEYDIVH
810
LEHETLVLVV
820
TSTFGNGDPP
830
ENGEKFGCAL
840
MEMRHPNSVQ
850
EERKSYKVRF
860
NSVSSYSDSQ
870
KSSGDGPDLR
880
DNFESAGPLA
890
NVRFSVFGLG
900
SRAYPHFCAF
910
GHAVDTLLEE
920
LGGERILKMR
930
EGDELCGQEE
940
AFRTWAKKVF
950
KAACDVFCVG
960
DDVNIEKANN
970
SLISNDRSWK
980
RNKFRLTFVA
990
EAPELTQGLS
1000
NVHKKRVSAA
1010
RLLSRQNLQS
1020
PKSSRSTIFV
1030
RLHTNGSQEL
1040
QYQPGDHLGV
1050
FPGNHEDLVN
1060
ALIERLEDAP
1070
PVNQMVKVEL
1080
LEERNTALGV
1090
ISNWTDELRL
1100
PPCTIFQAFK
1110
YYLDITTPPT
1120
PLQLQQFASL
1130
ATSEKEKQRL
1140
LVLSKGLQEY
1150
EEWKWGKNPT
1160
IVEVLEEFPS
1170
IQMPATLLLT
1180
QLSLLQPRYY
1190
SISSSPDMYP
1200
DEVHLTVAIV
1210
SYRTRDGEGP
1220
IHHGVCSSWL
1230
NRIQADELVP
1240
CFVRGAPSFH
1250
LPRNPQVPCI
1260
LVGPGTGIAP
1270
FRSFWQQRQF
1280
DIQHKGMNPC
1290
PMVLVFGCRQ
1300
SKIDHIYREE
1310
TLQAKNKGVF
1320
RELYTAYSRE
1330
PDKPKKYVQD
1340
ILQEQLAESV
1350
YRALKEQGGH
1360
IYVCGDVTMA
1370
ADVLKAIQRI
1380
MTQQGKLSAE
1390
DAGVFISRMR
1400
DDNRYHEDIF
1410
GVTLRTYEVT
1420
NRLRSESIAF
1430
IEESKKDTDE
VFSS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0034618 | arginine binding |
| Molecular Function | GO:0046870 | cadmium ion binding |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0010181 | FMN binding |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0004517 | nitric-oxide synthase activity |
| Molecular Function | GO:0035605 | peptidyl-cysteine S-nitrosylase activity |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Molecular Function | GO:0034617 | tetrahydrobiopterin binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0006527 | L-arginine catabolic process |
| Biological Process | GO:0033555 | multicellular organismal response to stress |
| Biological Process | GO:0007520 | myoblast fusion |
| Biological Process | GO:0045776 | negative regulation of blood pressure |
| Biological Process | GO:0051926 | negative regulation of calcium ion transport |
| Biological Process | GO:0010523 | negative regulation of calcium ion transport into cytosol |
| Biological Process | GO:0043267 | negative regulation of potassium ion transport |
| Biological Process | GO:0051612 | negative regulation of serotonin uptake |
| Biological Process | GO:0006809 | nitric oxide biosynthetic process |
| Biological Process | GO:0007263 | nitric oxide mediated signal transduction |
| Biological Process | GO:0106071 | positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1905026 | positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:1902307 | positive regulation of sodium ion transmembrane transport |
| Biological Process | GO:0098735 | positive regulation of the force of heart contraction |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| Biological Process | GO:0055117 | regulation of cardiac muscle contraction |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0060078 | regulation of postsynaptic membrane potential |
| Biological Process | GO:0002028 | regulation of sodium ion transport |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0006941 | striated muscle contraction |
| Biological Process | GO:0099163 | synaptic signaling by nitric oxide |
| Biological Process | GO:0042311 | vasodilation |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.