Search Results
Overview
| Uniprot ID | P29508 |
|---|---|
| Protein Name | Serpin B3 |
| Gene Name | SERPINB3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 69 | VTENTTGKAATYHVD |
Function
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1)
Protein Sequence
10
MNSLSEANTK
20
FMFDLFQQFR
30
KSKENNIFYS
40
PISITSALGM
50
VLLGAKDNTA
60
QQIKKVLHFD
70
QVTENTTGKA
80
ATYHVDRSGN
90
VHHQFQKLLT
100
EFNKSTDAYE
110
LKIANKLFGE
120
KTYLFLQEYL
130
DAIKKFYQTS
140
VESVDFANAP
150
EESRKKINSW
160
VESQTNEKIK
170
NLIPEGNIGS
180
NTTLVLVNAI
190
YFKGQWEKKF
200
NKEDTKEEKF
210
WPNKNTYKSI
220
QMMRQYTSFH
230
FASLEDVQAK
240
VLEIPYKGKD
250
LSMIVLLPNE
260
IDGLQKLEEK
270
LTAEKLMEWT
280
SLQNMRETRV
290
DLHLPRFKVE
300
ESYDLKDTLR
310
TMGMVDIFNG
320
DADLSGMTGS
330
RGLVLSGVLH
340
KAFVEVTEEG
350
AEAAAATAVV
360
GFGSSPTSTN
370
EEFHCNHPFL
380
FFIRQNKTNS
390
ILFYGRFSSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.