Search Results
Overview
| Uniprot ID | P29536 |
|---|---|
| Protein Name | Leiomodin-1 |
| Gene Name | LMOD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 293 | SKTKTPEKQTPSGPT |
| 565 | TQRKMGDKVLPAQEK |
| 57 | RQRNQTEKQSTGVYN |
Function
Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments
Protein Sequence
10
MSRVAKYRRQ
20
VSEDPDIDSL
30
LETLSPEEME
40
ELEKELDVVD
50
PDGSVPVGLR
60
QRNQTEKQST
70
GVYNREAMLN
80
FCEKETKKLM
90
QREMSMDESK
100
QVETKTDAKN
110
GEERGRDASK
120
KALGPRRDSD
130
LGKEPKRGGL
140
KKSFSRDRDE
150
AGGKSGEKPK
160
EEKIIRGIDK
170
GRVRAAVDKK
180
EAGKDGRGEE
190
RAVATKKEEE
200
KKGSDRNTGL
210
SRDKDKKREE
220
MKEVAKKEDD
230
EKVKGERRNT
240
DTRKEGEKMK
250
RAGGNTDMKK
260
EDEKVKRGTG
270
NTDTKKDDEK
280
VKKNEPLHEK
290
EAKDDSKTKT
300
PEKQTPSGPT
310
KPSEGPAKVE
320
EEAAPSIFDE
330
PLERVKNNDP
340
EMTEVNVNNS
350
DCITNEILVR
360
FTEALEFNTV
370
VKLFALANTR
380
ADDHVAFAIA
390
IMLKANKTIT
400
SLNLDSNHIT
410
GKGILAIFRA
420
LLQNNTLTEL
430
RFHNQRHICG
440
GKTEMEIAKL
450
LKENTTLLKL
460
GYHFELAGPR
470
MTVTNLLSRN
480
MDKQRQKRLQ
490
EQRQAQEAKG
500
EKKDLLEVPK
510
AGAVAKGSPK
520
PSPQPSPKPS
530
PKNSPKKGGA
540
PAAPPPPPPP
550
LAPPLIMENL
560
KNSLSPATQR
570
KMGDKVLPAQ
580
EKNSRDQLLA
590
AIRSSNLKQL
600
KKVEVPKLLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0005865 | striated muscle thin filament |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0045010 | actin nucleation |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0030239 | myofibril assembly |
| Biological Process | GO:0051694 | pointed-end actin filament capping |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.