Search Results
Overview
| Uniprot ID | P29797 |
|---|---|
| Protein Name | Guanine nucleotide-binding protein G(s) subunit alpha |
| Gene Name | GNAS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | MGCLGNSKTEDQRNE |
Function
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2
Protein Sequence
10
MGCLGNSKTE
20
DQRNEEKAQR
30
EANKKIEKQL
40
QKDKQVYRAT
50
HRLLLLGAGE
60
SGKSTIVKQM
70
RILHVNGFNG
80
DEKATKVQDI
90
KNNLKEAIET
100
IVAAMSNLVP
110
PVELANPENQ
120
FRVDYILSVM
130
NVPDFDFPPE
140
FYEHAKALWE
150
DEGVRACYER
160
SNEYQLIDCA
170
QYFLDKIDVI
180
KQDDYVPSDQ
190
DLLRCRVLTS
200
GIFETKFQVD
210
KVNFHMFDVG
220
GQRDERRKWI
230
QCFNDVTAII
240
FVVASSSYNM
250
VIREDNQTNR
260
LQEALNLFKS
270
IWNNRWLRTI
280
SVILFLNKQD
290
LLAEKVLAGK
300
SKIELFVLDD
310
RLFQERPFSF
320
IEDYFPEFAR
330
YTTPEDATPE
340
PGEDPRVTRA
350
KYFIRDEFLR
360
ISTASGDGRH
370
YCYPHFTCAV
380
DTENIRRVFN
390
DCRDIIQRMH
LRQYELL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005834 | heterotrimeric G-protein complex |
| Molecular Function | GO:0010856 | adenylate cyclase activator activity |
| Molecular Function | GO:0031698 | beta-2 adrenergic receptor binding |
| Molecular Function | GO:0051430 | corticotropin-releasing hormone receptor 1 binding |
| Molecular Function | GO:0031748 | D1 dopamine receptor binding |
| Molecular Function | GO:0031683 | G-protein beta/gamma-subunit complex binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0005159 | insulin-like growth factor receptor binding |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0031852 | mu-type opioid receptor binding |
| Biological Process | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway |
| Biological Process | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0007606 | sensory perception of chemical stimulus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.