Overview
| Uniprot ID | P30009 |
|---|
| Protein Name | Myristoylated alanine-rich C-kinase substrate |
|---|
| Gene Name | Marcks |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 165 |
KLSGFSFKKSKKEAG |
| 169 |
FSFKKSKKEAGEGAE |
Function
Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:24662485). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis. During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages. Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (PubMed:24662485)
Protein Sequence
10
MGAQFSKTAA
20
KGEAAAERPG
30
EAAVASSPSK
40
ANGQENGHVK
50
VNGDASPAAA
60
EPGAKEELQA
70
NGSAPAADKE
80
EPASGGAATP
90
AAADKDEAAA
100
APEPGAATAD
110
KEAAEAEPAE
120
PGSPSAETEG
130
ASASSTSSPK
140
AEDGAAPSPS
150
SETPKKKKKR
160
FSFKKSFKLS
170
GFSFKKSKKE
180
AGEGAEAEGA
190
TADGAKDEAA
200
AAAGGDAAAA
210
PGEQAGGAGA
220
EGAEGGESRE
230
AEAAEPEQPE
240
QPEQPAAEEP
250
RAEEPSEAVG
260
EKAEEPAPGA
270
TADDAPSAAG
280
PEQEAPAATD
290
EPAASAAPSA
300
SPEPQPECSP
EAPPAPVAE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0032432 |
actin filament bundle |
| Cellular Component |
GO:0043679 |
axon terminus |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0033391 |
chromatoid body |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0044307 |
dendritic branch |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0042585 |
germinal vesicle |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0043226 |
organelle |
| Cellular Component |
GO:0001520 |
outer dense fiber |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0099571 |
postsynaptic cytoskeleton |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Cellular Component |
GO:0099523 |
presynaptic cytosol |
| Cellular Component |
GO:0042734 |
presynaptic membrane |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Molecular Function |
GO:0005543 |
phospholipid binding |
| Molecular Function |
GO:0005080 |
protein kinase C binding |
| Biological Process |
GO:0051764 |
actin crosslink formation |
| Biological Process |
GO:0051017 |
actin filament bundle assembly |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0031589 |
cell-substrate adhesion |
| Biological Process |
GO:0007417 |
central nervous system development |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0007005 |
mitochondrion organization |
| Biological Process |
GO:0021915 |
neural tube development |
| Biological Process |
GO:0022008 |
neurogenesis |
| Biological Process |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
| Biological Process |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0008360 |
regulation of cell shape |
| Biological Process |
GO:1905274 |
regulation of modification of postsynaptic actin cytoskeleton |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
| Biological Process |
GO:0003229 |
ventricular cardiac muscle tissue development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.