Search Results

Overview

Uniprot ID	P30038
Protein Name	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Gene Name	ALDH4A1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
104	ADKSLLNKAIEAALA
114	EAALAARKEWDLKPI
130	DRAQIFLKAADMLSG
146	RRAEILAKTMVGQGK
296	PTFKHLWKQVAQNLD
31	WKHTSSLKVANEPVL
318	LAGECGGKNFHFVHR
347	AFEYGGQKCSACSRL
402	KSFARIKKWLEHARS
509	GNFYINDKSTGSIVG
52	PERDALQKALKDLKG
531	RASGTNDKPGGPHYI
552	QVIKETHKPLGDWSY
93	NHGHKVAKFCYADKS
99	AKFCYADKSLLNKAI

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes

Protein Sequence

10 MLLPAPALRR 20 ALLSRPWTGA 30 GLRWKHTSSL 40 KVANEPVLAF 50 TQGSPERDAL 60 QKALKDLKGR 70 MEAIPCVVGD 80 EEVWTSDVQY 90 QVSPFNHGHK 100 VAKFCYADKS 110 LLNKAIEAAL 120 AARKEWDLKP 130 IADRAQIFLK 140 AADMLSGPRR 150 AEILAKTMVG 160 QGKTVIQAEI 170 DAAAELIDFF 180 RFNAKYAVEL 190 EGQQPISVPP 200 STNSTVYRGL 210 EGFVAAISPF 220 NFTAIGGNLA 230 GAPALMGNVV 240 LWKPSDTAML 250 ASYAVYRILR 260 EAGLPPNIIQ 270 FVPADGPLFG 280 DTVTSSEHLC 290 GINFTGSVPT 300 FKHLWKQVAQ 310 NLDRFHTFPR 320 LAGECGGKNF 330 HFVHRSADVE 340 SVVSGTLRSA 350 FEYGGQKCSA 360 CSRLYVPHSL 370 WPQIKGRLLE 380 EHSRIKVGDP 390 AEDFGTFFSA 400 VIDAKSFARI 410 KKWLEHARSS 420 PSLTILAGGK 430 CDDSVGYFVE 440 PCIVESKDPQ 450 EPIMKEEIFG 460 PVLSVYVYPD 470 DKYKETLQLV 480 DSTTSYGLTG 490 AVFSQDKDVV 500 QEATKVLRNA 510 AGNFYINDKS 520 TGSIVGQQPF 530 GGARASGTND 540 KPGGPHYILR 550 WTSPQVIKET 560 HKPLGDWSYA YMQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003842	L-glutamate gamma-semialdehyde dehydrogenase activity
Biological Process	GO:0006562	L-proline catabolic process
Biological Process	GO:0010133	L-proline catabolic process to L-glutamate
Biological Process	GO:0006560	proline metabolic process
Biological Process	GO:0019470	trans-4-hydroxy-L-proline catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.