Overview
| Uniprot ID | P30039 |
|---|
| Protein Name | Phenazine biosynthesis-like domain-containing protein |
|---|
| Gene Name | PBLD |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 192 |
LQVENTGKVKGLILT |
| 194 |
VENTGKVKGLILTLK |
| 2 |
******MKLPIFIAD |
| 248 |
WSQHLGKKEMHAFQC |
| 37 |
LDEDMHQKIAREMNL |
| 52 |
SETAFIRKLHPTDNF |
Function
Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response (PubMed:39362857, PubMed:39589880, PubMed:39779683). PBLD enhances IFN-I signaling via multiple pathways (PubMed:39362857, PubMed:39589880, PubMed:39779683). Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication (PubMed:39362857). Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (PubMed:39779683). Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection (PubMed:39589880). Acts as a tumor suppressor, regulating development of various cancers (PubMed:23687415, PubMed:26594798)
Protein Sequence
10
MKLPIFIADA
20
FTARAFRGNP
30
AAVCLLENEL
40
DEDMHQKIAR
50
EMNLSETAFI
60
RKLHPTDNFA
70
QSSCFGLRWF
80
TPASEVPLCG
90
HATLASAAVL
100
FHKIKNMNST
110
LTFVTLSGEL
120
RARRAEDGIV
130
LDLPLYPAHP
140
QDFHEVEDLI
150
KTAIGNTLVQ
160
DICYSPDTQK
170
LLVRLSDVYN
180
RSFLENLKVN
190
TENLLQVENT
200
GKVKGLILTL
210
KGEPGGQTQA
220
FDFYSRYFAP
230
WVGVAEDPVT
240
GSAHAVLSSY
250
WSQHLGKKEM
260
HAFQCSHRGG
270
ELGISLRPDG
280
RVDIRGGAAV
VLEGTLTA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Molecular Function |
GO:0003824 |
catalytic activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0140374 |
antiviral innate immune response |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0030277 |
maintenance of gastrointestinal epithelium |
| Biological Process |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0032481 |
positive regulation of type I interferon production |
| Biological Process |
GO:0032479 |
regulation of type I interferon production |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.