Search Results
Overview
| Uniprot ID | P30040 |
|---|---|
| Protein Name | Endoplasmic reticulum resident protein 29 |
| Gene Name | ERP29 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | LNMELSEKYKLDKES |
| 109 | MELSEKYKLDKESYP |
| 182 | EARQALLKQGQDNLS |
| 192 | QDNLSSVKETQKKWA |
| 54 | YKVIPKSKFVLVKFD |
| 69 | TQYPYGEKQDEFKRL |
Function
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER
Protein Sequence
10
MAAAVPRAAF
20
LSPLLPLLLG
30
FLLLSAPHGG
40
SGLHTKGALP
50
LDTVTFYKVI
60
PKSKFVLVKF
70
DTQYPYGEKQ
80
DEFKRLAENS
90
ASSDDLLVAE
100
VGISDYGDKL
110
NMELSEKYKL
120
DKESYPVFYL
130
FRDGDFENPV
140
PYTGAVKVGA
150
IQRWLKGQGV
160
YLGMPGCLPV
170
YDALAGEFIR
180
ASGVEARQAL
190
LKQGQDNLSS
200
VKETQKKWAE
210
QYLKIMGKIL
220
DQGEDFPASE
230
MTRIARLIEK
240
NKMSDGKKEE
250
LQKSLNILTA
260
FQKKGAEKEE
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0050709 | negative regulation of protein secretion |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0009306 | protein secretion |
| Biological Process | GO:0043335 | protein unfolding |
| Biological Process | GO:1902235 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.