Search Results

Overview

Uniprot IDP30044
Protein NamePeroxiredoxin-5, mitochondrial
Gene NamePRDX5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 AFTPGCSKTHLPGFV
116 VEQAEALKAKGVQVV
142 GEWGRAHKAEGKVRL
83 VNLAELFKGKKGVLF
86 AELFKGKKGVLFGVP

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events

Protein Sequence

10 MGLAGVCALR 20 RSAGYILVGG 30 AGGQSAAAAA 40 RRYSEGEWAS 50 GGVRSFSRAA 60 AAMAPIKVGD 70 AIPAVEVFEG 80 EPGNKVNLAE 90 LFKGKKGVLF 100 GVPGAFTPGC 110 SKTHLPGFVE 120 QAEALKAKGV 130 QVVACLSVND 140 AFVTGEWGRA 150 HKAEGKVRLL 160 ADPTGAFGKE 170 TDLLLDDSLV 180 SIFGNRRLKR 190 FSMVVQDGIV 200 KALNVEPDGT 210 GLTCSLAPNI ISQL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0043231 intracellular membrane-bounded organelle
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0016209 antioxidant activity
Molecular Function GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004601 peroxidase activity
Molecular Function GO:0072541 peroxynitrite reductase activity
Molecular Function GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0008379 thioredoxin peroxidase activity
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0042744 hydrogen peroxide catabolic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0051354 negative regulation of oxidoreductase activity
Biological Process GO:0016480 negative regulation of transcription by RNA polymerase III
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:2001057 reactive nitrogen species metabolic process
Biological Process GO:0060785 regulation of apoptosis involved in tissue homeostasis
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.