Search Results
Overview
| Uniprot ID | P30048 |
|---|---|
| Protein Name | Thioredoxin-dependent peroxide reductase, mitochondrial |
| Gene Name | PRDX3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 149 | AWINTPRKNGGLGHM |
| 217 | EETLRLVKAFQYVET |
| 241 | TPDSPTIKPSPAASK |
| 248 | KPSPAASKEYFQKVN |
| 253 | ASKEYFQKVNQ**** |
| 91 | DLSLDDFKGKYLVLF |
| 93 | SLDDFKGKYLVLFFY |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0102039 | NADH-dependent peroxiredoxin activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0030099 | myeloid cell differentiation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0033673 | negative regulation of kinase activity |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.