Search Results

Overview

Uniprot ID	P30049
Protein Name	ATP synthase F(1) complex subunit delta, mitochondrial
Gene Name	ATP5F1D
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
136	AAKANLEKAQAELVG
165	EANEALVKALE****

Function

Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (PubMed:29499186)

Protein Sequence

10 MLPAALLRRP 20 GLGRLVRHAR 30 AYAEAAAAPA 40 AASGPNQMSF 50 TFASPTQVFF 60 NGANVRQVDV 70 PTLTGAFGIL 80 AAHVPTLQVL 90 RPGLVVVHAE 100 DGTTSKYFVS 110 SGSIAVNADS 120 SVQLLAEEAV 130 TLDMLDLGAA 140 KANLEKAQAE 150 LVGTADEATR 160 AEIQIRIEAN EALVKALE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045259	proton-transporting ATP synthase complex
Molecular Function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly
Biological Process	GO:0015986	proton motive force-driven ATP synthesis
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Biological Process	GO:0046688	response to copper ion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.